HYOU1 and NXPE4

		HYOU1	NXPE4
Description		hypoxia up-regulated 1	neurexophilin and PC-esterase domain family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Endoplasmic Reticulum Chaperone Complex Extracellular Exosome Endocytic Vesicle Lumen	Extracellular Region Extracellular Exosome
	Molecular Function	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Response To Ischemia Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Stress Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Cellular Response To Hypoxia Regulation Of Cellular Response To Stress Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Scavenging by Class F Receptors Scavenging by Class F Receptors XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Post-bronchodilator lung function in asthma (FVC) ( 32989782)	Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 23128233 28067908)
Interacting Genes		4 interacting genes: CDC42 CEBPA LINC01554 SEL1L	1 interacting genes: SRPK2
Entrez ID		10525	54827
HPRD ID		03448	12607
Ensembl ID		ENSG00000149428	ENSG00000137634
Uniprot IDs		A0A384P5T6 A0A494C039 A0A8Q3SHG4 B3KXH0 B7Z602 B7Z766 Q6IN67 Q9Y4L1	Q6UWF7
PDB IDs
Enriched GO Terms of Interacting Partners?		Macrophage Differentiation Interleukin-1 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating SH3 Domain Binding Positive Regulation Of Filopodium Assembly Myeloid Leukocyte Differentiation Positive Regulation Of Macrophage Activation	Regulation Of Neuron Apoptotic Process Nuclear Speck Organization Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway R-loop Processing Endoplasmic Reticulum Chaperone Complex Negative Regulation Of Cellular Response To Hypoxia Nuclear Body Organization Adenyl-nucleotide Exchange Factor Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endocytic Vesicle Lumen Smooth Endoplasmic Reticulum Regulation Of Cellular Response To Hypoxia Positive Regulation Of Viral Genome Replication 14-3-3 Protein Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway ATP-dependent Protein Folding Chaperone Peptidyl-serine Phosphorylation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Negative Regulation Of Response To Endoplasmic Reticulum Stress ATP Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Viral Process Response To Ischemia
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