HYOU1 and TMEM245

		HYOU1	TMEM245
Description		hypoxia up-regulated 1	transmembrane protein 245
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Endoplasmic Reticulum Chaperone Complex Extracellular Exosome Endocytic Vesicle Lumen	Membrane
	Molecular Function	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Response To Ischemia Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Stress Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Cellular Response To Hypoxia Regulation Of Cellular Response To Stress Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Scavenging by Class F Receptors Scavenging by Class F Receptors XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Post-bronchodilator lung function in asthma (FVC) ( 32989782)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Menarche (age at onset) ( 25231870) Sulfasalazine-induced agranulocytosis ( 28762467)
Interacting Genes		4 interacting genes: CDC42 CEBPA LINC01554 SEL1L
Entrez ID		10525	23731
HPRD ID		03448	09866
Ensembl ID		ENSG00000149428	ENSG00000106771
Uniprot IDs		A0A384P5T6 A0A494C039 A0A8Q3SHG4 B3KXH0 B7Z602 B7Z766 Q6IN67 Q9Y4L1	H7C0G1 Q9H330
PDB IDs
Enriched GO Terms of Interacting Partners?		Macrophage Differentiation Interleukin-1 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating SH3 Domain Binding Positive Regulation Of Filopodium Assembly Myeloid Leukocyte Differentiation Positive Regulation Of Macrophage Activation	Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Localization To Ciliary Inversin Compartment Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Chaperone Complex Negative Regulation Of Cellular Response To Hypoxia Adenyl-nucleotide Exchange Factor Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endocytic Vesicle Lumen Smooth Endoplasmic Reticulum Regulation Of Cellular Response To Hypoxia Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway ATP-dependent Protein Folding Chaperone Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Response To Ischemia Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Signaling Protein Localization To Cilium
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