HYOU1 and RBM7

		HYOU1	RBM7
Description		hypoxia up-regulated 1	RNA binding motif protein 7
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Endoplasmic Reticulum Chaperone Complex Extracellular Exosome Endocytic Vesicle Lumen	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATP-dependent Protein Folding Chaperone	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding Protein Binding SnRNA Binding 14-3-3 Protein Binding Pre-mRNA Intronic Binding
	Biological Process	Response To Ischemia Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Stress Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Cellular Response To Hypoxia Regulation Of Cellular Response To Stress Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Alternative MRNA Splicing, Via Spliceosome SnRNA Catabolic Process Meiotic Cell Cycle
Pathways		Scavenging by Class F Receptors Scavenging by Class F Receptors XBP1(S) activates chaperone genes	mRNA Splicing - Major Pathway Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Nuclear RNA decay
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Post-bronchodilator lung function in asthma (FVC) ( 32989782)	Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		4 interacting genes: CDC42 CEBPA LINC01554 SEL1L	27 interacting genes: APOBEC3C BAG4 CCDC85B CCDC88B CHERP CPSF7 DDX17 DHX8 DMRTB1 EVI5L EXOSC7 EXOSC8 HMG20A HNRNPK KHDRBS1 KHDRBS3 KRT31 QKI RBM10 RBM4 RBMX RBPMS SF1 SF3B2 SNRPA SRSF3 TFIP11
Entrez ID		10525	10179
HPRD ID		03448	11488
Ensembl ID		ENSG00000149428	ENSG00000076053
Uniprot IDs		A0A384P5T6 A0A494C039 A0A8Q3SHG4 B3KXH0 B7Z602 B7Z766 Q6IN67 Q9Y4L1	G3V1T9 J3KPD3 Q9Y580
PDB IDs			2M8H 5IQQ 5LXR 5LXY 7S7B 7S7C
Enriched GO Terms of Interacting Partners?		Macrophage Differentiation Interleukin-1 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating SH3 Domain Binding Positive Regulation Of Filopodium Assembly Myeloid Leukocyte Differentiation Positive Regulation Of Macrophage Activation	RNA Processing MRNA Metabolic Process MRNA Processing Nucleic Acid Binding RNA Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Binding RNA Metabolic Process RNA Splicing Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Catalytic Step 2 Spliceosome Nucleoplasm Negative Regulation Of MRNA Metabolic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Pre-mRNA Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Splicing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasmic Stress Granule Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process MiRNA Binding Exoribonuclease Complex Negative Regulation Of RNA Metabolic Process Identical Protein Binding Regulation Of Gene Expression Negative Regulation Of Gene Expression Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Speck Regulation Of Macromolecule Biosynthetic Process U4 SnRNA 3'-end Processing Macromolecule Metabolic Process
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