STAG1 and GUK1

		STAG1	GUK1
Description		STAG1 cohesin complex component	guanylate kinase 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol Cilium Cohesin Complex Nuclear Matrix Nuclear Body Mitotic Cohesin Complex Mitotic Spindle Pole	Photoreceptor Inner Segment Cytoplasm Mitochondrion Cytosol
	Molecular Function	Chromatin Binding Protein Binding	Nucleotide Binding GMP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Chromosome Segregation Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Cell Division Mitotic Spindle Assembly	Purine Nucleotide Metabolic Process DGDP Biosynthetic Process Xenobiotic Metabolic Process Nucleobase-containing Small Molecule Interconversion GDP-mannose Metabolic Process Glycoprotein Transport GMP Metabolic Process DGMP Metabolic Process DATP Metabolic Process GDP Biosynthetic Process
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Interconversion of nucleotide di- and triphosphates Azathioprine ADME
Drugs			Guanosine-5'-Monophosphate
Diseases
GWAS		A body shape index ( 34021172) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 25673413 28892062) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Central corneal thickness ( 32528159 29760442 31798171) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Dentures ( 31235808) General risk tolerance (MTAG) ( 30643258) HDL cholesterol ( 30275531) Height ( 25282103) Intraocular pressure ( 29617998) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Multisite chronic pain ( 31194737 33830993) Myocardial infarction ( 33532862) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Plateletcrit ( 32888494) Schizophrenia ( 30285260 29483656 28991256 25056061) Waist circumference adjusted for body mass index ( 34021172)	Coronary artery disease ( 29212778)
Interacting Genes		7 interacting genes: CALM1 DSCAM RAD21 SMAD2 SMAD9 STAG2 WFDC5	4 interacting genes: HNRNPD LCOR NLGN3 VHL
Entrez ID		10274	2987
HPRD ID		05076	00755
Ensembl ID		ENSG00000118007	ENSG00000143774
Uniprot IDs		Q8WVM7	Q16774 Q6IBG8
PDB IDs		5QSM 5QSN 5QSO 5QSP 5QSQ 5QSR 5QSS 5QST 5QSU 5QSV 5QSW 5QSX 5QSY 5QSZ 6QB5 6R7O 6RRC 6RRK 6WG3 7W1M	6NUI 8PTS
Enriched GO Terms of Interacting Partners?		Cohesin Complex Meiotic Cohesin Complex Sister Chromatid Cohesion Heteromeric SMAD Protein Complex SMAD Protein Complex Establishment Of Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion I-SMAD Binding Chromatin Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion SMAD Protein Signal Transduction Calcium Channel Complex Spindle Pole Chromosome, Centromeric Region Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum DGDP Biosynthetic Process GDP Biosynthetic Process Organ Growth Condensed Nuclear Chromosome Calcitriol Binding Lithocholic Acid Binding Histone H2B Ubiquitin Ligase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Nucleoplasm Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Homomeric SMAD Protein Complex Negative Regulation Of Phosphate Transmembrane Transport Nuclear Receptor-mediated Bile Acid Signaling Pathway Bile Acid Nuclear Receptor Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Roof Of Mouth Development Intracellular Signal Transduction Regulation Of Cardiac Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transporter Activity Glycoprotein Transport Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Cis-regulatory Region Sequence-specific DNA Binding Establishment Of Meiotic Sister Chromatid Cohesion Chromosome Organization	Cellular Response To Estradiol Stimulus Hepatocyte Dedifferentiation Cellular Response To Putrescine Response To Estradiol Histone Deacetylase Binding Circadian Regulation Of Translation Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse Response To Rapamycin Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Transcription Elongation Factor Activity Establishment Of Mitotic Sister Chromatid Cohesion Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Cohesin Complex Asymmetric, Glutamatergic, Excitatory Synapse Inhibitory Postsynaptic Potential Positive Regulation Of Glutamate Receptor Signaling Pathway Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neuron To Neuron Synapse Presynaptic Membrane Organization CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Glutamate Receptor Signaling Pathway Neurexin Family Protein Binding Presynapse Assembly Cellular Response To Nitric Oxide Negative Regulation Of Catabolic Process Regulation Of Telomere Capping Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Histone Methyltransferase Binding Negative Regulation Of RNA Metabolic Process Cellular Response To Reactive Nitrogen Species Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Response To Nitric Oxide Response To Ether Regulation Of Cellular Response To Hypoxia Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
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