STAG1 and SMC1B

Number of citations of the paper that reports this interaction (PubMedID 26344197)
49

Data Source:
BioGRID (biochemical)

		STAG1	SMC1B
Description		STAG1 cohesin complex component	structural maintenance of chromosomes 1B
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol Cilium Cohesin Complex Nuclear Matrix Nuclear Body Mitotic Cohesin Complex Mitotic Spindle Pole	Chromosome, Centromeric Region Condensed Nuclear Chromosome Synaptonemal Complex Lateral Element Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Meiotic Cohesin Complex
	Molecular Function	Chromatin Binding Protein Binding	Nucleotide Binding DNA Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	Chromosome Segregation Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Cell Division Mitotic Spindle Assembly	Sister Chromatid Cohesion Chromosome Organization Meiotic Cell Cycle
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Meiotic synapsis
Drugs
Diseases
GWAS		A body shape index ( 34021172) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 25673413 28892062) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Central corneal thickness ( 32528159 29760442 31798171) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Dentures ( 31235808) General risk tolerance (MTAG) ( 30643258) HDL cholesterol ( 30275531) Height ( 25282103) Intraocular pressure ( 29617998) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Multisite chronic pain ( 31194737 33830993) Myocardial infarction ( 33532862) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Plateletcrit ( 32888494) Schizophrenia ( 30285260 29483656 28991256 25056061) Waist circumference adjusted for body mass index ( 34021172)	Height ( 28552196) Peanut allergy (maternal genetic effects) ( 29489655)
Interacting Genes		7 interacting genes: CALM1 DSCAM RAD21 SMAD2 SMAD9 STAG2 WFDC5	1 interacting genes: SMC3
Entrez ID		10274	27127
HPRD ID		05076	10564
Ensembl ID		ENSG00000118007	ENSG00000077935
Uniprot IDs		Q8WVM7	Q8NDV3
PDB IDs		5QSM 5QSN 5QSO 5QSP 5QSQ 5QSR 5QSS 5QST 5QSU 5QSV 5QSW 5QSX 5QSY 5QSZ 6QB5 6R7O 6RRC 6RRK 6WG3 7W1M
Enriched GO Terms of Interacting Partners?		Cohesin Complex Meiotic Cohesin Complex Sister Chromatid Cohesion Heteromeric SMAD Protein Complex SMAD Protein Complex Establishment Of Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion I-SMAD Binding Chromatin Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion SMAD Protein Signal Transduction Calcium Channel Complex Spindle Pole Chromosome, Centromeric Region Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum DGDP Biosynthetic Process GDP Biosynthetic Process Organ Growth Condensed Nuclear Chromosome Calcitriol Binding Lithocholic Acid Binding Histone H2B Ubiquitin Ligase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Nucleoplasm Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Homomeric SMAD Protein Complex Negative Regulation Of Phosphate Transmembrane Transport Nuclear Receptor-mediated Bile Acid Signaling Pathway Bile Acid Nuclear Receptor Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Roof Of Mouth Development Intracellular Signal Transduction Regulation Of Cardiac Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transporter Activity Glycoprotein Transport Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Cis-regulatory Region Sequence-specific DNA Binding Establishment Of Meiotic Sister Chromatid Cohesion Chromosome Organization	Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Spindle Pole Sister Chromatid Cohesion Mitotic Spindle Assembly Mitotic Spindle Organization Spindle Assembly Nuclear Matrix Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Organization Chromosome, Centromeric Region Membraneless Organelle Assembly Establishment Of Meiotic Sister Chromatid Cohesion Chromosome Organization Meiotic Cohesin Complex Mediator Complex Binding Microtubule Cytoskeleton Organization Cell Division Chromatin Binding Lateral Element Chromosome Organelle Assembly Mitotic Sister Chromatid Cohesion Microtubule-based Process Dynein Complex Binding Cytoskeleton Organization Chromatin Nuclear Lumen Beta-tubulin Binding Microtubule Motor Activity Cis-regulatory Region Sequence-specific DNA Binding Meiotic Cell Cycle Stem Cell Population Maintenance Maintenance Of Cell Number Regulation Of DNA Replication Double-stranded DNA Binding Mitotic Cell Cycle Chromosome Segregation Cellular Component Assembly Organelle Organization
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