DCAF7 and SPDYA

		DCAF7	SPDYA
Description		DDB1 and CUL4 associated factor 7	speedy/RINGO cell cycle regulator family member A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Nuclear Body Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex	Chromosome, Telomeric Region XY Body Nucleus Nuclear Envelope Nucleoplasm
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding Protein Kinase Binding Protein Kinase Activator Activity
	Biological Process	Protein Ubiquitination	G1/S Transition Of Mitotic Cell Cycle DNA Damage Response Male Meiotic Nuclear Division Spermatogenesis Positive Regulation Of Cell Population Proliferation Telomere Capping Positive Regulation Of Protein Kinase Activity Oogenesis Meiotic Attachment Of Telomere To Nuclear Envelope Establishment Of Protein Localization To Telomere
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		7 interacting genes: APP ATP13A2 BMPR1B DYRK1B LIG1 PWP2 YWHAG	5 interacting genes: AQP1 CDK2 CDK5 CDKN1B FBXO7
Entrez ID		10238	245711
HPRD ID		09340	18095
Ensembl ID		ENSG00000136485	ENSG00000163806
Uniprot IDs		P61962	A0A384MTT5 Q5MJ70
PDB IDs			5UQ1 5UQ2 5UQ3 7E34
Enriched GO Terms of Interacting Partners?		Cellular Response To Manganese Ion Response To Manganese Ion Cellular Response To Stress	Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Response To Nitric Oxide Potassium Ion Transport Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Metal Ion Transport Regulation Of Cell Cycle G1/S Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Cell Cycle Cyclin Binding Monoatomic Cation Transport Sensory Perception Of Pain Regulation Of Cell Cycle Process Positive Regulation Of DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Monoatomic Ion Transport Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cellular Senescence Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Cyclin-dependent Protein Kinase Regulator Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Cell Cycle Regulation Of Locomotion G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Sensory Perception Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion Regulation Of Mitotic Cell Cycle Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Acetylcholine Receptor Activator Activity Negative Regulation Of Developmental Growth Negative Regulation Of Cardiac Muscle Tissue Regeneration
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