AASS and FSCN3

		AASS	FSCN3
Description		aminoadipate-semialdehyde synthase	fascin actin-bundling protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Ruffle Cytoplasm Cytoskeleton Microvillus Actin Cytoskeleton Lamellipodium Filopodium Growth Cone Cell Projection Membrane
	Molecular Function	Transcription Corepressor Activity Catalytic Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Oxidoreductase Activity Histone Binding Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity	Actin Binding Protein-macromolecule Adaptor Activity Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lysine Catabolic Process L-lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Cell Migration Actin Filament Bundle Assembly
Pathways		Lysine catabolism
Drugs		Glutamic acid NADH NADPH L-Saccharopine
Diseases		Hyperlysinemia
GWAS		Opioid dependence (time to event) ( 34124712)	Adiponectin levels ( 33562295) Type 2 diabetes ( 26818947)
Interacting Genes		2 interacting genes: OGT WEE2-AS1
Entrez ID		10157	29999
HPRD ID		05489	17020
Ensembl ID		ENSG00000008311	ENSG00000106328
Uniprot IDs		A0A7P0T9N4 A4D0W4 Q9UDR5	A0A140VK18 Q9NQT6
PDB IDs		5L76 5L78 5O1N 5O1O 5O1P 8DDA 8E8T 8E8U 8E8V
Enriched GO Terms of Interacting Partners?			Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity L-lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Lysine Catabolic Process Amide Catabolic Process Acetyl-CoA Metabolic Process Aspartate Family Amino Acid Metabolic Process Acyl-CoA Metabolic Process L-amino Acid Catabolic Process Proteinogenic Amino Acid Catabolic Process Amino Acid Catabolic Process L-amino Acid Metabolic Process Histone Binding Alpha-amino Acid Metabolic Process Transcription Corepressor Activity Carboxylic Acid Catabolic Process Sulfur Compound Metabolic Process Amino Acid Metabolic Process Catalytic Activity
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