G3BP1 and HMGXB3

		G3BP1	HMGXB3
Description		G3BP stress granule assembly factor 1	HMG-box containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Perikaryon	Cellular_component Nucleus
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity DNA/RNA Helicase Activity Ribosomal Small Subunit Binding Molecular Condensate Scaffold Activity	DNA Binding
	Biological Process	Immune System Process Ras Protein Signal Transduction Positive Regulation Of Type I Interferon Production Stress Granule Assembly Innate Immune Response Defense Response To Virus Positive Regulation Of Stress Granule Assembly Negative Regulation Of Canonical Wnt Signaling Pathway	Biological_process
Pathways		SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)	Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Monocyte percentage of white cells ( 32888494)
Interacting Genes		23 interacting genes: APP CEBPA CSK DTX1 EPHA8 FBXO25 GABARAP GABARAPL1 IL7R LCK LGALS8 LINC01554 OGT PIN1 PPIA RASA1 SPOP TRIM21 TRIM25 UBAP2L USP10 USP13 USP2	6 interacting genes: ANXA7 CDK4 CDKN1A PFDN1 SMN1 TK1
Entrez ID		10146	22993
HPRD ID		06569	19515
Ensembl ID		ENSG00000145907	ENSG00000113716
Uniprot IDs		Q13283 Q5U0Q1 Q6ZP53	Q12766 Q562E5
PDB IDs		3Q90 4FCJ 4FCM 4IIA 5FW5 6TA7 7S17 7SUO 7XHF 7XHG 8TH1 8TH5 8TH6 8TH7 8V1L
Enriched GO Terms of Interacting Partners?		Protein Modification Process Regulation Of Intracellular Signal Transduction Ubiquitin Protein Ligase Binding Autophagy Protein Peptidyl-prolyl Isomerization Regulation Of Signal Transduction Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Cytoplasm Stress Granule Assembly Regulation Of Proteolysis Positive Regulation Of Cell Activation Post-translational Protein Modification Cellular Developmental Process Protein Metabolic Process Regulation Of Protein K48-linked Ubiquitination Regulation Of Cell Activation Regulation Of Cell Communication Regulation Of Signaling T Cell Costimulation Heparan Sulfate Binding Organelle Assembly Protein Monoubiquitination Mitophagy Cellular Response To Nitrogen Starvation Macroautophagy Regulation Of Stress Granule Assembly Mononuclear Cell Differentiation Cysteine-type Endopeptidase Activity Hemopoiesis Macromolecule Metabolic Process Response To Cytokine Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Response To Peptide Neuron Remodeling Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Intracellular Signal Transduction Regulation Of Protein Stability Leukocyte Differentiation Regulation Of Proteasomal Protein Catabolic Process Autophagosome Positive Regulation Of Protein Catabolic Process Regulation Of Leukocyte Cell-cell Adhesion Protein Ubiquitination Suppression Of Viral Release By Host GABA Receptor Binding Regulation Of T Cell Activation Regulation Of Protein Metabolic Process	Response To Phorbol 13-acetate 12-myristate Cyclin Binding Cell Cycle G1/S Phase Transition Positive Regulation Of Fibroblast Proliferation G1/S Transition Of Mitotic Cell Cycle Regulation Of Fibroblast Proliferation Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cyclin-dependent Protein Kinase Holoenzyme Complex PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Ras Protein Signal Transduction Heparan Sulfate N-sulfotransferase Activity Heparan Sulfate N-deacetylase Activity N-acetylglucosamine Deacetylase Activity Thymidine Kinase Activity DNA/RNA Helicase Activity Cyclin D2-CDK4 Complex Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Synthesis Involved In Mitotic DNA Replication Cellular Response To Cell-matrix Adhesion Perikaryon Mitotic Cell Cycle Phase Transition Thymidine Biosynthetic Process Cell Cycle Phase Transition Cellular Response To Ionomycin Oncogene-induced Cell Senescence Stress-induced Premature Senescence Heparin Proteoglycan Biosynthetic Process Prefoldin Complex Thymidine Metabolic Process Positive Regulation Of Stress Granule Assembly Chromaffin Granule Membrane Embryonic Neurocranium Morphogenesis
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