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KIR2DS2 and HLA-C
Number of citations of the paper that reports this interaction (PMID
11172020
)
13
Data Source:
BioGRID
(pull down)
KIR2DS2
HLA-C
Gene Name
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
major histocompatibility complex, class I, C
Image
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Membrane
Golgi Membrane
Extracellular Region
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Phagocytic Vesicle Membrane
Early Endosome Membrane
MHC Class I Protein Complex
Extracellular Vesicular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Receptor Binding
Peptide Antigen Binding
TAP Binding
Biological Process
Immune Response
Signal Transduction
Innate Immune Response
Regulation Of Immune Response
Positive Regulation Of T Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
Immune Response
Viral Process
Cytokine-mediated Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Innate Immune Response
Regulation Of Immune Response
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Pathways
DAP12 interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Adaptive Immune System
Interferon gamma signaling
Interferon Signaling
Endosomal/Vacuolar pathway
Cytokine Signaling in Immune system
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Drugs
Diseases
GWAS
AIDS progression (
19115949
)
Atopic dermatitis (
23042114
)
Beta-2 microglubulin plasma levels (
23417110
)
Chronic obstructive pulmonary disease-related biomarkers (
23144326
)
Complement C3 and C4 levels (
23028341
)
Coronary heart disease (
22319020
)
Crohn's disease (
23128233
)
Height (
23563607
)
HIV-1 control (
21051598
20041166
)
Hypothyroidism (
22493691
)
Nasopharyngeal carcinoma (
20512145
)
Protein quantitative trait loci (
18464913
)
Psoriasis (
20953188
20953190
18369459
18364390
19169254
)
Psoriatic arthritis (
20953186
)
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) (
21912425
)
Vitiligo (
20526339
)
White blood cell count (
21738480
)
Protein-Protein Interactions
1 interactors:
HLA-C
20 interactors:
B2M
BATF2
CALR
CD8A
CDC25A
CXCR4
HSPA5
KIR2DL1
KIR2DL2
KIR2DL3
KIR2DS1
KIR2DS2
KIR2DS4
LILRB1
LILRB2
PRRG4
TANK
TAP2
TAPBP
YBX1
Entrez ID
100132285
3107
HPRD ID
00829
Ensembl ID
ENSG00000204525
Uniprot IDs
K7R1S5
P43631
Q6H2G8
O19617
P10321
Q6R739
Q95HC2
PDB IDs
1M4K
3BZF
Enriched GO Terms of Interacting Partners
?
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Positive Regulation Of T Cell Mediated Cytotoxicity
Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Leukocyte Mediated Cytotoxicity
Positive Regulation Of T Cell Mediated Immunity
Positive Regulation Of Cell Killing
Regulation Of Leukocyte Mediated Cytotoxicity
Type I Interferon Signaling Pathway
Cellular Response To Type I Interferon
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Response To Type I Interferon
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of Adaptive Immune Response
Cellular Response To Interferon-gamma
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Response To Interferon-gamma
Regulation Of Adaptive Immune Response
Antigen Processing And Presentation Of Peptide Antigen
Antigen Processing And Presentation
Cytokine-mediated Signaling Pathway
Viral Process
Cellular Response To Cytokine Stimulus
Positive Regulation Of Immune Response
Response To Cytokine
Innate Immune Response
Immune System Process
Regulation Of Immune System Process
Regulation Of Immune Response
Immune Response
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Immune Response-inhibiting Signal Transduction
Defense Response
Response To Biotic Stimulus
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation
Response To Stress
Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent
Fc Receptor Mediated Inhibitory Signaling Pathway
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Cell Activation
Response To Other Organism
Regulation Of Dendritic Cell Differentiation
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Peptide Antigen
Response To Stimulus
Leukocyte Activation
Antigen Processing And Presentation Of Endogenous Antigen
Single Organismal Cell-cell Adhesion
Positive Regulation Of Immune System Process
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Leukocyte Differentiation
Lymphocyte Activation
Innate Immune Response
Response To External Stimulus
Immune Response-regulating Signaling Pathway
Dendritic Cell Differentiation
Negative Regulation Of Calcium Ion Transport
Peptide Antigen Assembly With MHC Class I Protein Complex
Cytotoxic T Cell Differentiation
Natural Killer Cell Inhibitory Signaling Pathway
Regulation Of Protein Folding In Endoplasmic Reticulum
Negative Regulation Of Interferon-beta Secretion
Peptide Antigen Stabilization
Negative Regulation Of Transforming Growth Factor-beta Secretion
Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Positive Regulation Of Nuclease Activity
Signal Transduction
Tagcloud
?
alloreactive
cd107a
cd137
cd16
cd56
cd69
commensurate
depended
facs
gated
gbm
gbms
glioblastomas
granzyme
immunogenotype
k562
killer
killers
mismatch
mismatches
nk
nkg2d
nontumor
notwithstanding
rank
sorted
subpopulations
survived
Tagcloud (Difference)
?
alloreactive
cd107a
cd137
cd16
cd56
cd69
commensurate
depended
facs
gated
gbm
gbms
glioblastomas
granzyme
immunogenotype
k562
killer
killers
mismatch
mismatches
nk
nkg2d
nontumor
notwithstanding
rank
sorted
subpopulations
survived
Tagcloud (Intersection)
?