TUBB6

Description		tubulin beta 6 class V
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Intercellular Bridge Extracellular Exosome Mitotic Spindle
	Molecular Function	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		CYT997 Artenimol
Diseases
GWAS
Interacting Genes		6 interacting genes: DUX4 HTRA2 LINC00941 LINC01554 OGT SUMO2
Entrez ID		84617
HPRD ID		11349
Ensembl ID		ENSG00000176014
Uniprot IDs		B3KS31 B4E386 K7EJ64 Q9BUF5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Apoptotic Process Mitochondrial Membrane Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein Processing Protein O-acetylglucosaminyltransferase Activity Response To Herbicide Pentacyclic Triterpenoid Metabolic Process Negative Regulation Of Type 2 Mitophagy Promoter-enhancer Loop Anchoring Activity Negative Regulation Of G0 To G1 Transition Cell Death Programmed Cell Death Regulation Of Transcription By Glucose Mitochondrial Protein Catabolic Process Serine-type Endopeptidase Complex Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand NSL Complex Ubiquitin Ligase Inhibitor Activity CD40 Receptor Complex Negative Regulation Of Mitophagy Protein Maturation Regulation Of Transcription By RNA Polymerase II
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