TAGLN2

Description		transgelin 2
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Actin Cytoskeleton Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Actin Filament Organization Epithelial Cell Differentiation
Pathways		Platelet degranulation
Drugs		Artenimol
Diseases
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease-related phenotypes ( 25557950) Mean platelet volume ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: APP EHD2 FILNC1 SUMO2
Entrez ID		8407
HPRD ID		06864
Ensembl ID		ENSG00000158710
Uniprot IDs		A0A384MTL2 P37802
PDB IDs		1WYM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Presynapse Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Postsynapse Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Positive Regulation Of Endocytic Recycling Peptidase Activator Activity Early Endosome Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding
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