ITPKC

Description		inositol-trisphosphate 3-kinase C
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Nucleotide Binding Inositol Hexakisphosphate Kinase Activity Calmodulin Binding ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Kinase Activity Transferase Activity
	Biological Process	Inositol Phosphate Biosynthetic Process Phosphatidylinositol Phosphate Biosynthetic Process Cellular Response To Calcium Ion
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases
GWAS		Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Kawasaki disease ( 22081228 33106546 33772158)
Interacting Genes		2 interacting genes: PPP3CC VHL
Entrez ID		80271
HPRD ID		09400
Ensembl ID		ENSG00000086544
Uniprot IDs		A0A8V8TPP3 Q96DU7
PDB IDs		2A98
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Synaptic Vesicle Recycling Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Serine/threonine Phosphatase Complex Positive Regulation Of Calcium Ion Import Across Plasma Membrane Calmodulin-dependent Protein Phosphatase Activity Calcineurin Complex Transcription Elongation Factor Activity Positive Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Regulation Of Synaptic Vesicle Recycling Calcineurin-mediated Signaling Regulation Of Cellular Response To Hypoxia Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Amyloid Fibril Formation Negative Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of DNA-templated Transcription, Elongation Protein Serine/threonine Kinase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Calcineurin-mediated Signaling Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transport Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of TORC1 Signaling Protein Modification Process Mitochondrion Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Receptor Signaling Pathway Via JAK-STAT
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