GNPTAB

Description		N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Calcium Ion Binding Protein Binding Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Metal Ion Binding
	Biological Process	Lysosome Organization Protein Secretion Protein Transport N-glycan Processing To Lysosome Secretion Of Lysosomal Enzymes Carbohydrate Phosphorylation Establishment Of Localization In Cell
Pathways
Drugs
Diseases		Mucolipidosis II and III, including: Mucolipidosis II / I-cell disease; Mucolipidosis III A / Pseudo-Hurler polydystrophy; Mucolipidosis III C
GWAS		Bone mineral density (total hip) ( 29883787) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: AEN APP DISC1 DSCAM DSCR9 FAM90A1 MAPK1 PSMA1 STAMBPL1 ZNF250
Entrez ID		79158
HPRD ID		11350
Ensembl ID		ENSG00000111670
Uniprot IDs		Q3T906
PDB IDs		2N6D 7S05 7S06 9BGF 9BGG
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Axon Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Monoatomic Cation Homeostasis Trans-synaptic Signaling Chemical Synaptic Transmission Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Regulation Of Chemotaxis Cell Body Positive Regulation Of Chemotaxis Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Leukocyte Chemotaxis Neuron Recognition Regulation Of Inflammatory Response Lipoprotein Particle Synaptic Signaling Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Intracellular Monoatomic Ion Homeostasis Microglia Development Glial Cell Development Positive Regulation Of G Protein-coupled Receptor Internalization Synapse Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Axon Extension Positive Regulation Of Axon Extension Positive Regulation Of Axonogenesis Cellular Response To Amino Acid Starvation Cytosine Metabolic Process Interleukin-34-mediated Signaling Pathway Response To Amino Acid Starvation Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone DNA Exonuclease Activity Positive Regulation Of Cellular Component Organization Monoatomic Ion Homeostasis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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