SLC1A2

Description		solute carrier family 1 member 2
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axon Axolemma Vesicle Presynaptic Membrane Cell Body Neuron Projection Terminus Membrane Raft Synapse Astrocyte Projection Membrane Protein Complex Glutamatergic Synapse
	Molecular Function	L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity Cysteine Transmembrane Transporter Activity Metal Ion Binding
	Biological Process	Glutathione Biosynthetic Process Monoatomic Ion Transport Neurotransmitter Transport Amino Acid Transport Chemical Synaptic Transmission Nervous System Development Visual Behavior Response To Xenobiotic Stimulus Response To Light Stimulus Response To Wounding Neutral Amino Acid Transport L-glutamate Transmembrane Transport Telencephalon Development Adult Behavior Multicellular Organism Growth Response To Amino Acid Positive Regulation Of D-glucose Import Protein Homotrimerization Transepithelial Transport L-aspartate Transmembrane Transport D-aspartate Import Across Plasma Membrane Cellular Response To Cocaine Monoatomic Anion Transmembrane Transport Import Into Cell L-glutamate Import Across Plasma Membrane Neurotransmitter Reuptake L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Cysteine Transmembrane Transport
Pathways		Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle SLC-mediated transport of amino acids
Drugs		Glutamic acid
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Corpus callosum mid-anterior volume ( 31530798) Essential tremor ( 22764253) Health literacy ( 31250787) Lung function (FEV1/FVC) ( 30804560) Medication use (thyroid preparations) ( 31015401) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Relative hand skill in reading disability ( 24068947) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Type 1 diabetes ( 34127860) Type 2 diabetes ( 30718926) Vitiligo ( 27723757)
Interacting Genes		2 interacting genes: AJUBA GRB2
Entrez ID		6506
HPRD ID		02625
Ensembl ID		ENSG00000110436
Uniprot IDs		A0A2R8Y860 A0A2R8YFE3 A0A2U3TZS7 A2A2U1 P43004
PDB IDs		7VR7 7VR8 7XR4 7XR6
Enriched GO Terms of Interacting Partners?		Guanyl-nucleotide Exchange Factor Adaptor Activity Cell-cell Junction Positive Regulation Of Protein-containing Complex Assembly Grb2-EGFR Complex Regulation Of Protein-containing Complex Assembly Neurotrophin TRKA Receptor Binding Epidermal Growth Factor Receptor Binding Positive Regulation Of Cellular Component Organization Phosphotyrosine Residue Binding Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity COP9 Signalosome Positive Regulation Of Cellular Component Biogenesis Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity T Cell Costimulation Cytoskeleton Organization Schwann Cell Development Endodermal Cell Differentiation Centrosome Branching Involved In Labyrinthine Layer Morphogenesis Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Actin Filament Polymerization Insulin Receptor Substrate Binding Ephrin Receptor Binding Vesicle Membrane Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Hippo Signaling Lamellipodium Assembly Regulation Of Cellular Response To Hypoxia Focal Adhesion Assembly Cell-substrate Junction Organization Wound Healing, Spreading Of Cells Negative Regulation Of Hippo Signaling Cell-substrate Junction Assembly Wound Healing, Spreading Of Epidermal Cells Protein Kinase Activator Activity Alpha-catenin Binding Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Lamellipodium Organization Regulation Of Natural Killer Cell Mediated Cytotoxicity B Cell Receptor Signaling Pathway Golgi Apparatus MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Natural Killer Cell Mediated Immunity Fibroblast Growth Factor Receptor Signaling Pathway Glial Cell Development Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Receptor Internalization Cellular Response To Ionizing Radiation
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