RLBP1

Description		retinaldehyde binding protein 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Cell Body
	Molecular Function	11-cis Retinal Binding Protein Binding Retinol Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Vitamin A Metabolic Process Visual Perception
Pathways		The retinoid cycle in cones (daylight vision) The retinoid cycle in cones (daylight vision) The canonical retinoid cycle in rods (twilight vision) Defective visual phototransduction due to RDH5 loss of function
Drugs
Diseases		Newfoundland rod-cone dystrophy (NFRCD) Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Advanced age-related macular degeneration ( 28813576) Age-related macular degeneration (SNP x mitochondrial G12771A interaction) ( 28813576) Schizophrenia ( 28991256)
Novel Interacting Genes		1 novel interacting genes: NR2F2
Interacting Genes		4 interacting genes: APP KLHL8 NHERF1 RDH5
Entrez ID		6017
HPRD ID		01572
Ensembl ID		ENSG00000140522
Uniprot IDs		P12271
PDB IDs		3HX3 3HY5 4CIZ 4CJ6
Enriched GO Terms of Interacting Partners?		Growth Factor Receptor Binding Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Cell Body Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Homodimerization Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization 11-cis-retinol Dehydrogenase (NAD+) Activity Lymphatic Endothelial Cell Fate Commitment Radial Pattern Formation Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Renal Phosphate Ion Absorption Negative Regulation Of Wnt Signaling Pathway Regulation Of Spontaneous Synaptic Transmission Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Cell Migration Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Microtubule-based Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Synapse Structure Or Activity Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Nervous System Process
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