AICDA

Description		activation induced cytidine deaminase
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amidines Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	MRNA Processing Regulation Of Macromolecule Biosynthetic Process Somatic Diversification Of Immunoglobulins Somatic Hypermutation Of Immunoglobulin Genes Cytidine To Uridine Editing B Cell Differentiation Regulation Of Nuclear Cell Cycle DNA Replication Defense Response To Bacterium Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Isotype Switching Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response To Virus DNA Cytosine Deamination Cellular Response To Lipopolysaccharide
Pathways		Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Takayasu arteritis ( 25604533)
Interacting Genes		5 interacting genes: APP NEDD4L PSME3 RNF126 RPA1
Entrez ID		57379
HPRD ID		05585
Ensembl ID		ENSG00000111732
Uniprot IDs		Q546Y9 Q6QJ80 Q7Z599 Q9GZX7
PDB IDs		5JJ4 5W0R 5W0U 5W0Z 5W1C
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Hemopoiesis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Protein Catabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Recombinational Repair Double-strand Break Repair Via Homologous Recombination Proteasome Activator Complex Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis Protein K48-linked Ubiquitination Protein Monoubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Single-stranded Telomeric DNA Binding Negative Regulation Of Protein Localization Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Double-strand Break Repair Negative Regulation Of Potassium Ion Export Across Plasma Membrane DNA Recombination
Tagcloud ?