TWNK

Description		twinkle mtDNA helicase
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GO Annotations	Cellular Component	Mitochondrial Chromosome Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Mitochondrial Nucleoid
	Molecular Function	Nucleotide Binding Protease Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Lipid Binding Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding 5'-3' DNA Helicase Activity
	Biological Process	DNA Replication DNA-templated DNA Replication Mitochondrial DNA Replication Mitochondrial Transcription Protein Hexamerization
Pathways		Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Mitochondrial heteroplasmy measurement ( 33731350)
Interacting Genes		3 interacting genes: AKTIP SMAD9 UBC
Entrez ID		56652
HPRD ID		05830
Ensembl ID		ENSG00000107815
Uniprot IDs		A0A2R8Y4V4 A0A2R8Y746 E5KSY5 Q96RR1 Q9H6V3
PDB IDs		7T8B 7T8C
Enriched GO Terms of Interacting Partners?
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