HEATR3

Description		HEAT repeat containing 3
Image		No pdb structure
GO Annotations	Cellular Component
	Molecular Function	Unfolded Protein Binding
	Biological Process	Protein Import Into Nucleus Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Erythrocyte Maturation
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Epilepsy ( 30531953) Esophageal cancer (squamous cell) ( 22960999) Glioblastoma ( 28346443) Glioma ( 28346443) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 28957414) Systemic lupus erythematosus ( 33272962) Testicular germ cell tumor ( 23666239 23666240 28604728 28604732) Uterine fibroids ( 31249589)
Novel Interacting Genes		1 novel interacting genes: GPT2
Interacting Genes		2 interacting genes: AKT1 CEBPA
Entrez ID		55027
HPRD ID		07945
Ensembl ID		ENSG00000155393
Uniprot IDs		Q7Z4Q2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Fat Cell Differentiation Integrated Stress Response Signaling Kinase Binding Response To Tumor Necrosis Factor Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Fat Cell Differentiation Regulation Of TRNA Methylation Cellular Response To Tumor Necrosis Factor RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Carbohydrate Homeostasis Positive Regulation Of Protein Localization To Endoplasmic Reticulum Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Regulation Of Ubiquitin-dependent Protein Catabolic Process Embryonic Organ Development Mitochondrion Organization Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Protein Catabolic Process TRNA (guanine-N7)-methylation Response To Ketone TORC2 Complex Binding Cellular Response To Rapamycin Small Molecule Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Cellular Response To Metal Ion SREBP-SCAP Complex Retention In Endoplasmic Reticulum CHOP-C/EBP Complex Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex L-alanine Metabolic Process L-alanine Catabolic Process L-alanine:2-oxoglutarate Aminotransferase Activity Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Fatty Acid Beta-oxidation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex
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