RSPO4

Gene Name		R-spondin 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	G-protein Coupled Receptor Binding Heparin Binding
	Biological Process	Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: LGR4
Entrez ID		343637
HPRD ID		18788
Ensembl ID		ENSG00000101282
Uniprot IDs		Q2I0M5
PDB IDs
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Metanephric Nephron Tubule Morphogenesis Cell Differentiation Involved In Metanephros Development Metanephric Tubule Morphogenesis Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Nephron Tubule Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Nephron Morphogenesis Negative Regulation Of Toll-like Receptor Signaling Pathway Male Genitalia Development Metanephric Epithelium Development Metanephros Morphogenesis Negative Regulation Of Cytokine Secretion Positive Regulation Of Kidney Development Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Regulation Of Toll-like Receptor Signaling Pathway Bone Mineralization Genitalia Development Bone Remodeling Glomerulus Development Regulation Of Morphogenesis Of A Branching Structure Biomineral Tissue Development Circadian Regulation Of Gene Expression Nephron Morphogenesis Renal Tubule Morphogenesis Epithelial Cell Proliferation Canonical Wnt Signaling Pathway Renal Tubule Development Negative Regulation Of Protein Secretion Kidney Morphogenesis Metanephros Development Tissue Remodeling Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cytokine Secretion Osteoblast Differentiation Nephron Development Positive Regulation Of Wnt Signaling Pathway Kidney Epithelium Development Negative Regulation Of Secretion By Cell Circadian Rhythm Negative Regulation Of Secretion Regulation Of Organ Morphogenesis Negative Regulation Of Protein Transport Male Sex Differentiation Negative Regulation Of Cytokine Production Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Ossification
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