TRIB2

Description		tribbles pseudokinase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Kinase Inhibitor Activity Protein Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Protein Phosphorylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-10 Production Regulation Of MAP Kinase Activity Negative Regulation Of Fat Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Cataracts ( 34127677) Chronotype ( 30696823) Dental caries ( 23064961) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Graves' disease ( 22922229) Heel bone mineral density ( 30598549) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Methadone dose in opioid dependence ( 28115739) Multiple sclerosis ( 24076602) Optic cup area ( 28073927 25631615) Pericardial adipose tissue adjusted for height and weight ( 27918534) Pericardial fat ( 27918534 22589742) Platelet count ( 32888494)
Interacting Genes		8 interacting genes: ACACA APP BTRC CEBPA PARVG PRMT6 SLAMF7 UBQLN4
Entrez ID		28951
HPRD ID		18224
Ensembl ID		ENSG00000071575
Uniprot IDs		Q92519
PDB IDs		7UPM
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Histone H2AR3 Methyltransferase Activity Malonyl-CoA Biosynthetic Process Ligase Activity Protein Tetramerization Acetyl-CoA Carboxylase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Memory Notch Signaling Pathway Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Response To Vitamin B2 C/EBP Complex Negative Regulation Of Autophagy Protein Phosphorylated Amino Acid Binding Negative Regulation Of Catabolic Process Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Amide Biosynthetic Process Positive Regulation Of Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of RNA Biosynthetic Process
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