ATP2C1

Description		ATPase secretory pathway Ca2+ transporting 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Endomembrane System Membrane Golgi Cisterna Membrane Cis-Golgi Network Membrane
	Molecular Function	Nucleotide Binding P-type Calcium Transporter Activity Calcium Ion Binding ATP Binding ATP Hydrolysis Activity Manganese Ion Binding Metal Ion Binding P-type Manganese Transporter Activity
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Manganese Ion Transport Intracellular Calcium Ion Homeostasis Epidermis Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Intracellular Manganese Ion Homeostasis Actin Cytoskeleton Organization Golgi Calcium Ion Homeostasis Golgi Calcium Ion Transport Positive Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Trans-Golgi Network Membrane Organization
Pathways		Ion transport by P-type ATPases
Drugs		Enflurane Isoflurane Ritodrine Methoxyflurane Desflurane Sevoflurane Calcium
Diseases		Hailey-Hailey disease; Benign familial pemphigus
GWAS		Refractive error ( 32231278) Restless legs syndrome ( 29029846) Waist circumference ( 28552196)
Novel Interacting Genes		1 novel interacting genes: GGCX
Interacting Genes		3 interacting genes: F2RL1 GPR35 GTF2IRD1
Entrez ID		27032
HPRD ID		05089
Ensembl ID		ENSG00000017260
Uniprot IDs		B4E295 B4E2Q0 P98194
PDB IDs		7YAG 7YAH 7YAI 7YAJ 7YAM 8IWP 8IWR 8IWS 8IWT 8IWU 8IWW
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Negative Regulation Of Transport Positive Regulation Of Renin Secretion Into Blood Stream Gamma-glutamyl Carboxylase Activity Transition Between Slow And Fast Fiber Proteinase-activated Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Secretion By Cell Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Vitamin Binding Negative Regulation Of Bone Development Positive Regulation Of Glomerular Filtration Negative Regulation Of Secretion Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Testosterone Biosynthetic Process Positive Regulation Of Killing Of Cells Of Another Organism Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Neurotransmitter Secretion C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Toll-like Receptor 3 Signaling Pathway Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly G Protein-coupled Receptor Activity Positive Regulation Of Phagocytosis, Engulfment Regulation Of Transport Regulation Of Glomerular Filtration Regulation Of Bone Development Vitamin K Metabolic Process Regulation Of Skeletal Muscle Adaptation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Defense Response To Bacterium Pseudopodium Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Protein Depolymerization Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure
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