ATP6V0A2

Description		ATPase H+ transporting V0 subunit a2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Acrosomal Vesicle Lysosomal Membrane Endosome Plasma Membrane Focal Adhesion Endosome Membrane Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Immune Response Vacuolar Acidification Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Golgi Lumen Acidification Proton Transmembrane Transport
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport
Drugs		Tiludronic acid
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		A body shape index ( 34021172) Adiponectin levels ( 22479202) Neutrophil count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		1 novel interacting genes: MPHOSPH9
Interacting Genes		2 interacting genes: CYTH2 DRD2
Entrez ID		23545
HPRD ID		16521
Ensembl ID		ENSG00000185344
Uniprot IDs		Q9Y487
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Synapse Structural Plasticity Dopamine Binding Regulation Of Renal Sodium Excretion Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Golgi Membrane G Protein-coupled Receptor Complex Catecholamine Uptake Dopamine Uptake Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Adenohypophysis Development Negative Regulation Of Dephosphorylation Response To Inactivity Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Neuron Migration Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Neuron-neuron Synaptic Transmission Interneuron Migration From The Subpallium To The Cortex Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Peristalsis Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Urine Volume Behavioral Response To Ethanol Negative Regulation Of Dopamine Receptor Signaling Pathway Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Dopamine Receptor Signaling Pathway Drinking Behavior Negative Regulation Of Circadian Rhythm Endocytosis Negative Regulation Of Catecholamine Secretion Inositol 1,4,5 Trisphosphate Binding Auditory Behavior Cellular Response To Ethanol Anatomical Structure Regression Negative Regulation Of Cellular Response To Hypoxia
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