AGA

Name	aspartylglucosaminidase
Structure
Interactors	3 interactors: ALB IGF2R KRTAP1-3
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Endoplasmic Reticulum Azurophil Granule Lumen
	Molecular Function	N4-(beta-N-acetylglucosaminyl)-L-asparaginase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Protein Deglycosylation
Pathways	Neutrophil degranulation
Diseases	Aspartylglucosaminuria (AGU)
GWAS	Chromosomal aberration frequency (chromatid type) ( 31586183 ) Colorectal cancer (calcium intake interaction) ( 25192705 ) Familial hepatitis B virus-related hepatocellular carcinoma ( 28662289 ) Metabolite levels ( 23823483 ) Motion sickness ( 25628336 ) Response to mTOR inhibitor (everolimus) ( 24009623 ) Serum metabolite levels ( 33031748 ) Serum selenium levels ( 23698163 )
Entrez ID	175
HPRD ID	01949
Ensembl ID	ENSG00000038002
Uniprot IDs	P20933
PDB IDs	1APY 1APZ
GO Terms Enriched among Interactors ?	Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Insulin-like Growth Factor Receptor Activity Response To Tetrachloromethane Toxic Substance Binding Negative Regulation Of Mitochondrial Depolarization Insulin-like Growth Factor II Binding Insulin-like Growth Factor Binding Clathrin Coat Retromer Complex Binding Nuclear Envelope Lumen Trans-Golgi Network Transport Vesicle Regulation Of Mitochondrial Depolarization Retinoic Acid Binding D-mannose Binding Antioxidant Activity Oxygen Binding Fatty Acid Binding G-protein Alpha-subunit Binding Insulin-like Growth Factor Receptor Signaling Pathway Host-mediated Activation Of Viral Process Phosphoprotein Binding Pyridoxal Phosphate Binding Regulation Of Membrane Depolarization Copper Ion Binding Animal Organ Regeneration Structural Constituent Of Skin Epidermis