NUP42

Description		nucleoporin 42
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Membrane Nuclear Membrane
	Molecular Function	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Export From Nucleus Nucleocytoplasmic Transport Protein Transport MRNA Transport
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS
Interacting Genes		5 interacting genes: APC GLE1 KRT34 LCOR NUP214
Entrez ID		11097
HPRD ID		14855
Ensembl ID		ENSG00000136243
Uniprot IDs		O15504
PDB IDs		6B4F 6B4I 6B4J
Enriched GO Terms of Interacting Partners?		RNA Export From Nucleus MRNA Export From Nucleus Nuclear Pore Cytoplasmic Side Of Nuclear Pore RNA Transport MRNA Transport Nuclear Export Inositol Hexakisphosphate Binding Nuclear Pore Cytoplasmic Filaments Nucleobase-containing Compound Transport Nuclear Envelope Positive Regulation Of Protein Localization To Centrosome Nuclear Transport Nucleocytoplasmic Transport
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