SLC26A1

Gene Name		solute carrier family 26 (anion exchanger), member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Secondary Active Sulfate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Sulfate Transmembrane Transporter Activity Anion:anion Antiporter Activity Oxalate Transmembrane Transporter Activity
	Biological Process	Carbohydrate Metabolic Process Xenobiotic Metabolic Process Ion Transport Chloride Transport Sulfate Transport Pathogenesis Oxalate Transport Glycosaminoglycan Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Transmembrane Transport Sulfate Transmembrane Transport Chloride Transmembrane Transport
Pathways		Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) MPS I - Hurler syndrome MPS IX - Natowicz syndrome Transport of inorganic cations/anions and amino acids/oligopeptides Glycosaminoglycan metabolism Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes SLC-mediated transmembrane transport Defective CHST14 causes EDS, musculocontractural type Defective UGT1A1 causes hyperbilirubinemia Myoclonic epilepsy of Lafora Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) MPS IIID - Sanfilippo syndrome D Glycogen storage diseases Defective CHST6 causes MCDC1 Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) MPS IV - Morquio syndrome A Phase II conjugation Cytosolic sulfonation of small molecules Transport and synthesis of PAPS Multifunctional anion exchangers Transport and synthesis of PAPS Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective SLC26A2 causes chondrodysplasias Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) MPS IIIC - Sanfilippo syndrome C MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: UBC
Entrez ID		10861
HPRD ID		15361
Ensembl ID		ENSG00000145217
Uniprot IDs		Q9H2B4
PDB IDs
Enriched GO Terms of Interacting Partners?		Viral Protein Processing Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Glycogen Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Ligase Activity Positive Regulation Of Type I Interferon Production DNA Damage Response, Signal Transduction By P53 Class Mediator Toll-like Receptor 4 Signaling Pathway Regulation Of ERBB Signaling Pathway Polysaccharide Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
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