CASP8AP2 and TRIM21

Number of citations of the paper that reports this interaction (PubMedID 20697732)
32

Data Source:
BioGRID (two hybrid)

		CASP8AP2	TRIM21
Description		caspase 8 associated protein 2	tripartite motif containing 21
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion PML Body	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Cytoplasmic Stress Granule SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex
	Molecular Function	Transcription Corepressor Activity Death Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process SUMO Polymer Binding	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fas Signaling Pathway Negative Regulation Of DNA-templated Transcription Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway	Autophagosome Assembly Protein Polyubiquitination Protein Monoubiquitination Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Stress Granule Assembly Response To Type II Interferon Stress Granule Disassembly Protein K27-linked Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Protein Autoubiquitination Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		SUMOylation of transcription cofactors	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31959851) Estimated glomerular filtration rate in non-diabetics ( 31451708) Femur bone mineral density x serum urate levels interaction ( 34046847) Major depressive disorder ( 29317602)	Lung cancer ( 28604730) Malaria ( 31844061)
Interacting Genes		21 interacting genes: CALM1 CASP10 CASP8 CREBBP CREM CTBP2 FADD FAS GLUL KLHL20 MX1 NAA10 NR3C2 PML RAD51 SP100 SREBF2 TCL1A TRAF2 TRIM21 UBE2I	87 interacting genes: AGO4 AIFM2 ALOX15B APC ATG5 CASP8AP2 CBX4 CDC34 CDKN1A CLSPN CUL1 CWC25 DAXX DCP2 DLGAP1-AS2 DMAP1 DZIP3 EHHADH ELAVL1 EXOC8 FADD FBXW11 FHOD1 G3BP1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 LPP MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NAT8 NIF3L1 PFKP PPP1CA RAB11FIP1 RAB11FIP5 RNF111 RO60 SAMHD1 SETD7 SIRT5 SKP2 STK3 TBK1 TCP11L1 TH TNS4 TP53 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2I UBE2L3 UBE2N UBE2V1 UBE2W USP15 USP2 USP4 VPS9D1 WEE2-AS1 XAF1 YJU2 YWHAZ ZBTB16
Entrez ID		9994	6737
HPRD ID		06048	00170
Ensembl ID		ENSG00000118412	ENSG00000132109
Uniprot IDs		Q9UKL3	P19474
PDB IDs		2LR8 6ANO 6AOZ 6AP0	2IWG 5JPX 5OLM 6FGA 6S53 7BBD 8A58 8Y58 8Y59 8Y5B 9QBA
Enriched GO Terms of Interacting Partners?		CD95 Death-inducing Signaling Complex Death Effector Domain Binding Ripoptosome Positive Regulation Of Signal Transduction Death-inducing Signaling Complex Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Identical Protein Binding PML Body Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Execution Phase Of Apoptosis Response To Cytokine Cytoplasm Response To Peptide Positive Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Apoptotic Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Apoptotic Process Apoptotic Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Nucleus TRAIL-activated Apoptotic Signaling Pathway Apoptotic Process Signal Transduction Cell Death Response To Stress Programmed Cell Death Regulation Of Apoptotic Signaling Pathway N-terminal Protein Amino Acid Acetylation Response To Type I Interferon Cellular Response To Mechanical Stimulus Positive Regulation Of Biosynthetic Process Negative Regulation Of Viral Process Cell Body Motor Neuron Apoptotic Process Negative Regulation Of RNA Metabolic Process	Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Protein Modification Process Protein Ubiquitination Cellular Response To Nitrogen Starvation Cytosol Ubiquitin Protein Ligase Binding Cellular Response To Nutrient Levels Catabolic Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Phosphatidylethanolamine Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Response To Nutrient Levels Mitophagy Response To Stress Cellular Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Cytoplasm Cellular Response To Starvation Autophagosome Organization Macromolecule Metabolic Process Protein K48-linked Ubiquitination Autophagy Of Mitochondrion Regulation Of Protein Ubiquitination Nucleus Regulation Of Canonical NF-kappaB Signal Transduction Response To Virus Proteolysis Response To Starvation Vacuole Organization Positive Regulation Of Protein Polyubiquitination Autophagosome Assembly TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Defense Response To Other Organism Negative Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Protein Ubiquitination PML Body Protein K63-linked Ubiquitination Macroautophagy
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