TRIM21 and AIFM2

Number of citations of the paper that reports this interaction (PubMedID 37587773)
66

Data Source:
BioGRID (pull down)

		TRIM21	AIFM2
Description		tripartite motif containing 21	AIF family member 2
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Cytoplasmic Stress Granule SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex	Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Mitochondrial Membrane
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Electron-transferring-flavoprotein Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Flavin Adenine Dinucleotide Binding
	Biological Process	Autophagosome Assembly Protein Polyubiquitination Protein Monoubiquitination Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Stress Granule Assembly Response To Type II Interferon Stress Granule Disassembly Protein K27-linked Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Protein Autoubiquitination Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Ubiquinone Metabolic Process Apoptotic Mitochondrial Changes Respiratory Electron Transport Chain Vitamin K Metabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Ferroptosis Regulation Of Cellular Response To Oxidative Stress Cellular Detoxification
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs
Diseases
GWAS		Lung cancer ( 28604730) Malaria ( 31844061)	Post bronchodilator FEV1/FVC ratio ( 26634245) Rheumatoid arthritis ( 30891314)
Interacting Genes		87 interacting genes: AGO4 AIFM2 ALOX15B APC ATG5 CASP8AP2 CBX4 CDC34 CDKN1A CLSPN CUL1 CWC25 DAXX DCP2 DLGAP1-AS2 DMAP1 DZIP3 EHHADH ELAVL1 EXOC8 FADD FBXW11 FHOD1 G3BP1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 LPP MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NAT8 NIF3L1 PFKP PPP1CA RAB11FIP1 RAB11FIP5 RNF111 RO60 SAMHD1 SETD7 SIRT5 SKP2 STK3 TBK1 TCP11L1 TH TNS4 TP53 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2I UBE2L3 UBE2N UBE2V1 UBE2W USP15 USP2 USP4 VPS9D1 WEE2-AS1 XAF1 YJU2 YWHAZ ZBTB16	3 interacting genes: CNPY4 PLXNB2 TRIM21
Entrez ID		6737	84883
HPRD ID		00170	09797
Ensembl ID		ENSG00000132109	ENSG00000042286
Uniprot IDs		P19474	Q9BRQ8
PDB IDs		2IWG 5JPX 5OLM 6FGA 6S53 7BBD 8A58 8Y58 8Y59 8Y5B 9QBA	8JSC 8WIK 8YO8 8YOQ 8YOX
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Protein Modification Process Protein Ubiquitination Cellular Response To Nitrogen Starvation Cytosol Ubiquitin Protein Ligase Binding Cellular Response To Nutrient Levels Catabolic Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Phosphatidylethanolamine Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Response To Nutrient Levels Mitophagy Response To Stress Cellular Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Cytoplasm Cellular Response To Starvation Autophagosome Organization Macromolecule Metabolic Process Protein K48-linked Ubiquitination Autophagy Of Mitochondrion Regulation Of Protein Ubiquitination Nucleus Regulation Of Canonical NF-kappaB Signal Transduction Response To Virus Proteolysis Response To Starvation Vacuole Organization Positive Regulation Of Protein Polyubiquitination Autophagosome Assembly TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Defense Response To Other Organism Negative Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Protein Ubiquitination PML Body Protein K63-linked Ubiquitination Macroautophagy	Regulation Of Protein Deubiquitination Stress Granule Disassembly Positive Regulation Of Protein Binding Negative Regulation Of Protein Deubiquitination TRNA Stabilization Excitatory Synapse Assembly Negative Regulation Of Translation In Response To Stress Positive Regulation Of Viral Entry Into Host Cell Suppression Of Viral Release By Host Protein K27-linked Ubiquitination Negative Regulation Of Viral Transcription Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Viral Transcription Negative Regulation Of Protein Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Translation In Response To Stress
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?