MED12 and MED13

Number of citations of the paper that reports this interaction (PubMedID 15175163)
0

Data Source:
HPRD (in vitro, in vivo)

		MED12	MED13
Description		mediator complex subunit 12	mediator complex subunit 13
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane Mediator Complex CKM Complex	Nucleus Nucleoplasm Membrane Mediator Complex CKM Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Somitogenesis Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Endoderm Development Heart Development Oligodendrocyte Development Schwann Cell Development Protein Ubiquitination Spinal Cord Development Neural Tube Development Somatic Stem Cell Population Maintenance Post-anal Tail Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Embryonic Neurocranium Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Transcription Initiation By RNA Polymerase II Axis Elongation Involved In Somitogenesis Embryonic Brain Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cholesterol Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II Triglyceride Homeostasis
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases		MED12-related disorders, including: Lujan-Fryns syndrome (LFS); Lujan syndrome; X-linked mental retardation with Marfanoid habitus; FG syndrome type 1 (FGS1); Opitz-Kaveggia syndrome FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Uterine fibroids ( 31649266)	Coffee consumption ( 31046077) Initial pursuit acceleration ( 29064472) Objective response to lithium treatment ( 26503763) PR segment duration ( 24850809)
Interacting Genes		17 interacting genes: CDK8 CEBPA ESR1 ESR2 GLI3 LYST MED1 MED13 MED26 MED8 MED9 NANOG PPARGC1A SGCE SOX9 SREBF1 TAF1	9 interacting genes: ENO1 ESR1 LCOR MED12 MED13L MED23 MED9 SREBF1 TSC22D2
Entrez ID		9968	9969
HPRD ID		02176	07229
Ensembl ID		ENSG00000184634	ENSG00000108510
Uniprot IDs		Q93074	Q9UHV7
PDB IDs		8TQ2 8TQC 8TQW	8T9D 8TQ2 8TQC 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mediator Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Regulation Of Transcription By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coregulator Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Core Mediator Complex Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Primary Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Stem Cell Proliferation DNA-binding Transcription Factor Activity Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Elongation Chromatin Binding Nuclear Estrogen Receptor Activity Mammary Gland Branching Involved In Pregnancy DNA Binding	Mediator Complex Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Binding RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity Axis Elongation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Core Mediator Complex Positive Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Cellular Response To Estradiol Stimulus Positive Regulation Of Macromolecule Metabolic Process Nuclear Estrogen Receptor Binding Transcription Coregulator Binding Positive Regulation Of Metabolic Process Nuclear Receptor Activity Transcription Coactivator Activity Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of MiRNA Transcription Nucleoplasm Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II Axis Elongation Involved In Somitogenesis Beta-catenin Binding Regulation Of DNA-templated Transcription Elongation Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Response To Estradiol Prostate Epithelial Cord Elongation
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