MED12 and MED9

Number of citations of the paper that reports this interaction (PubMedID 14638676)
0

Data Source:
HPRD (in vitro)

		MED12	MED9
Description		mediator complex subunit 12	mediator complex subunit 9
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane Mediator Complex CKM Complex	Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Protein Binding
	Biological Process	Somitogenesis Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Endoderm Development Heart Development Oligodendrocyte Development Schwann Cell Development Protein Ubiquitination Spinal Cord Development Neural Tube Development Somatic Stem Cell Population Maintenance Post-anal Tail Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Embryonic Neurocranium Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Transcription Initiation By RNA Polymerase II Axis Elongation Involved In Somitogenesis Embryonic Brain Development	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases		MED12-related disorders, including: Lujan-Fryns syndrome (LFS); Lujan syndrome; X-linked mental retardation with Marfanoid habitus; FG syndrome type 1 (FGS1); Opitz-Kaveggia syndrome FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Uterine fibroids ( 31649266)	Birth weight ( 31043758) Estimated glomerular filtration rate ( 31152163) Fasting glucose ( 34059833) Two-hour glucose ( 34059833)
Interacting Genes		17 interacting genes: CDK8 CEBPA ESR1 ESR2 GLI3 LYST MED1 MED13 MED26 MED8 MED9 NANOG PPARGC1A SGCE SOX9 SREBF1 TAF1	27 interacting genes: APP CBX4 CDK8 MED1 MED11 MED12 MED13 MED14 MED16 MED18 MED19 MED22 MED23 MED24 MED25 MED26 MED27 MED28 MED29 MED30 MED31 MED4 MED6 MED7 MED8 UBC USP47
Entrez ID		9968	55090
HPRD ID		02176	14383
Ensembl ID		ENSG00000184634	ENSG00000141026
Uniprot IDs		Q93074	Q9NWA0
PDB IDs		8TQ2 8TQC 8TQW	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mediator Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Regulation Of Transcription By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coregulator Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Core Mediator Complex Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Primary Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Stem Cell Proliferation DNA-binding Transcription Factor Activity Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Elongation Chromatin Binding Nuclear Estrogen Receptor Activity Mammary Gland Branching Involved In Pregnancy DNA Binding	Mediator Complex Core Mediator Complex Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Protein-DNA Complex Assembly Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Vitamin D Receptor Binding Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Protein-containing Complex Organization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coactivator Activity Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Thyroid Hormone Receptor Binding Positive Regulation Of Metabolic Process Ubiquitin Ligase Complex Somatic Stem Cell Population Maintenance Cellular Component Assembly Regulation Of Gene Expression Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Stem Cell Population Maintenance Maintenance Of Cell Number Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination CKM Complex
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