MRC2 and RB1CC1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		MRC2	RB1CC1
Description		mannose receptor C-type 2	RB1 inducible coiled-coil 1
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GO Annotations	Cellular Component	Focal Adhesion Membrane	Phagophore Assembly Site Autophagosome Membrane Nucleus Cytoplasm Lysosome Vacuole Endoplasmic Reticulum Membrane Cytosol Organelle Membrane Nuclear Membrane Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Binding Collagen Binding Carbohydrate Binding Signaling Receptor Activity	Protein Binding Protein Kinase Binding Protein-membrane Adaptor Activity Molecular Adaptor Activity
	Biological Process	Osteoblast Differentiation Endocytosis Collagen Catabolic Process	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Liver Development Autophagy Apoptotic Process Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Ribophagy Piecemeal Microautophagy Of The Nucleus Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Size Positive Regulation Of JNK Cascade Defense Response To Virus Reticulophagy Glycophagy Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes)	Macroautophagy
Drugs
Diseases
GWAS		Diastolic blood pressure ( 28135244 30578418) Heel bone mineral density ( 30598549) Pulse pressure ( 28135244 30578418) Systolic blood pressure ( 30578418)	Body size at age 10 ( 32376654) Immunoglobulin light chain (AL) amyloidosis (liver involvement) ( 28679651) Mitochondrial DNA copy number (white blood cells) ( 30704525) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		14 interacting genes: AKT1 BAG4 BRMS1 ESR2 MTDH NDEL1 PALB2 PAX2 PPM1D PTPN1 RAF1 RB1CC1 SLC26A4-AS1 XRCC3	35 interacting genes: ATG12 AZI2 BAP1 BLID CALCOCO2 COP1 EPSTI1 ERRFI1 EXOC1 GABARAP GABARAPL1 GABARAPL2 GLCE GREB1 HBP1 IL13RA2 IL24 ITIH5 LYPD3 MADD MECOM MRC2 NSD3 PSMC3IP PTK2 PTK2B RNF20 SYN1 THRSP UBC UMPS VAPA VHL VPS45 WIF1
Entrez ID		9902	9821
HPRD ID		10094	06019
Ensembl ID		ENSG00000011028	ENSG00000023287
Uniprot IDs		Q9UBG0	Q8TDY2
PDB IDs		5AO5 5AO6 5E4K 5E4L 5EW6	6DCE 6GMA 7CZG 7CZM 7D0E 7EA2 7EAA 8SOI 8SQZ 8SRM 8W6B 8YFK 8YFL 8YFM 8YFN 9C82 9D34
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Intracellular Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Fibroblast Migration Inner Cell Mass Cell Proliferation Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Stem Cell Population Maintenance Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Fluid Shear Stress Negative Regulation Of Macromolecule Metabolic Process NF-kappaB Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Carbohydrate Homeostasis Apoptotic Process Negative Regulation Of Metabolic Process Glucose Homeostasis Regulation Of Fibroblast Migration Negative Regulation Of RNA Metabolic Process Response To Fluid Shear Stress Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Programmed Cell Death Cell Death Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of TRNA Methylation Response To Epidermal Growth Factor	Autophagosome Membrane Autophagosome Cellular Response To Nitrogen Starvation Autophagosome Maturation Phosphatidylethanolamine Binding GABA Receptor Binding Autophagy Of Mitochondrion Macroautophagy Autophagosome Assembly Autophagosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-tubulin Binding Signal Complex Assembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein-containing Complex Disassembly Mitophagy Glycophagy Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process Ubiquitin Protein Ligase Binding Autophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Vacuole Organization Regulation Of Autophagosome Maturation Programmed Cell Death Cell Death ERBB Signaling Pathway Protein Localization To Endoplasmic Reticulum Positive Regulation Of Proteolysis Glycogen Catabolic Process Regulation Of Proteolysis Histone H3 Methyltransferase Activity Catabolic Process Polysaccharide Catabolic Process Regulation Of Macrophage Chemotaxis Cellular Response To Fluid Shear Stress Neurotransmitter Receptor Regulator Activity Orotidine-5'-phosphate Decarboxylase Activity Orotate Phosphoribosyltransferase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Golgi Membrane Phospholipid Binding Heparosan-N-sulfate-glucuronate 5-epimerase Activity Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H3K4 Dimethyltransferase Activity
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