SV2A and VPS45

		SV2A	VPS45
Description		synaptic vesicle glycoprotein 2A	vacuolar protein sorting 45 homolog
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Cell-cell Junction Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Cell Projection Neuron Projection Synapse Presynaptic Active Zone Presynapse Glutamatergic Synapse GABA-ergic Synapse	Golgi Membrane Endosome Golgi Apparatus Synaptic Vesicle Endosome Membrane Endomembrane System Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Kinase Binding Transmembrane Transporter Activity	Protein Binding
	Biological Process	Neurotransmitter Transport Intracellular Calcium Ion Homeostasis Chemical Synaptic Transmission Synaptic Vesicle Priming Transmembrane Transport	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport
Pathways		Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type F (botF) Toxicity of botulinum toxin type E (botE)	Intra-Golgi traffic SARS-CoV-2 modulates autophagy Factors involved in megakaryocyte development and platelet production
Drugs		Levetiracetam Brivaracetam Seletracetam
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Height ( 18391951 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1) ( 26635082)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hip circumference adjusted for BMI ( 34021172) Obesity in adult survivors of childhood cancer not exposed to cranial radiation ( 25963547) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Uric acid levels ( 21294900)
Interacting Genes		5 interacting genes: ATXN1 DNAJC5 LAMA5 LTB4R2 VPS45	18 interacting genes: BCAR3 CASP8 H2AC18 IGF1R LTAP1 PAX2 PTPN1 RAB13 RB1CC1 RBSN RPRD2 SNCA SNTG1 STX16 SV2A USP25 VPS11 VPS18
Entrez ID		9900	11311
HPRD ID		08922	10301
Ensembl ID		ENSG00000159164	ENSG00000136631
Uniprot IDs		B4E000 Q7L0J3	A0A2R8YE10 B7Z360 B7Z5D4 Q9NRW7
PDB IDs		4V11 8JLC 8JLE 8JLF 8JLG 8JLH 8JLI 8JS8 8JS9 8K77 8UO9 8UOA 8YF0 8YF1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Of Synaptic Cleft Laminin-5 Complex Laminin-11 Complex Ameboidal-type Cell Migration Laminin-10 Complex Neuromuscular Junction Synaptic Vesicle Leukotriene B4 Receptor Activity Leukotriene Receptor Activity POZ Domain Binding Leukotriene Signaling Pathway Trunk Neural Crest Cell Migration Morphogenesis Of A Polarized Epithelium Keratinocyte Migration Poly(G) Binding ATP-dependent Protein Binding Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Branching Involved In Salivary Gland Morphogenesis Cell Adhesion Mediator Activity Nuclear Inclusion Body Negative Regulation Of Adenylate Cyclase Activity	Regulation Of SNARE Complex Assembly Vesicle-mediated Transport Syntaxin Binding CORVET Complex Vacuole Organization Vesicle Docking Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Insulin Receptor Signaling Pathway Organelle Localization By Membrane Tethering Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway HOPS Complex Membrane Docking Endosomal Vesicle Fusion Synaptic Vesicle Priming Vesicle Fusion Organelle Membrane Fusion Negative Regulation Of Programmed Cell Death Insulin Receptor Binding Lysosomal Transport Early Endosome Organelle Fusion Synaptic Vesicle Synaptic Vesicle Membrane Regulation Of JNK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Membrane Fusion Negative Regulation Of Intracellular Signal Transduction Regulation Of Cytokine-mediated Signaling Pathway Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Response To Fibroblast Growth Factor Trans-Golgi Network To Recycling Endosome Transport Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ribophagy Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Vacuolar Transport Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Organelle Localization Negative Regulation Of Response To Endoplasmic Reticulum Stress Lysosome Regulation Of Signal Transduction Cellular Response To Glucose Stimulus
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