VPS45

Description		vacuolar protein sorting 45 homolog
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Synaptic Vesicle Endosome Membrane Endomembrane System Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding
	Biological Process	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport
Pathways		Intra-Golgi traffic SARS-CoV-2 modulates autophagy Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hip circumference adjusted for BMI ( 34021172) Obesity in adult survivors of childhood cancer not exposed to cranial radiation ( 25963547) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Uric acid levels ( 21294900)
Novel Interacting Genes		18 novel interacting genes: BCAR3 CASP8 H2AC18 IGF1R LTAP1 PAX2 PTPN1 RAB13 RB1CC1 RBSN RPRD2 SNCA SNTG1 STX16 SV2A USP25 VPS11 VPS18
Interacting Genes		18 interacting genes: BCAR3 CASP8 H2AC18 IGF1R LTAP1 PAX2 PTPN1 RAB13 RB1CC1 RBSN RPRD2 SNCA SNTG1 STX16 SV2A USP25 VPS11 VPS18
Entrez ID		11311
HPRD ID		10301
Ensembl ID		ENSG00000136631
Uniprot IDs		A0A2R8YE10 B7Z360 B7Z5D4 Q9NRW7
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of SNARE Complex Assembly Vesicle-mediated Transport Syntaxin Binding CORVET Complex Vacuole Organization Vesicle Docking Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Insulin Receptor Signaling Pathway Organelle Localization By Membrane Tethering Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway HOPS Complex Membrane Docking Endosomal Vesicle Fusion Synaptic Vesicle Priming Vesicle Fusion Organelle Membrane Fusion Negative Regulation Of Programmed Cell Death Insulin Receptor Binding Lysosomal Transport Early Endosome Organelle Fusion Synaptic Vesicle Synaptic Vesicle Membrane Regulation Of JNK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Membrane Fusion Negative Regulation Of Intracellular Signal Transduction Regulation Of Cytokine-mediated Signaling Pathway Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Response To Fibroblast Growth Factor Trans-Golgi Network To Recycling Endosome Transport Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ribophagy Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Vacuolar Transport Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Organelle Localization Negative Regulation Of Response To Endoplasmic Reticulum Stress Lysosome Regulation Of Signal Transduction Cellular Response To Glucose Stimulus
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