PJA2 and KSR2

Number of citations of the paper that reports this interaction (PubMedID 35918402)
73

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		PJA2	KSR2
Description		praja ring finger ubiquitin ligase 2	kinase suppressor of ras 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Centriolar Satellite Ciliary Basal Body Synapse Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Inflammatory Response Long-term Memory Regulation Of Protein Kinase A Signaling Protein Ubiquitination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Macrophage Activation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of P38MAPK Cascade	MAPK Cascade Ras Protein Signal Transduction Calcium-mediated Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of Cold-induced Thermogenesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Body mass index ( 29273807) Frontotemporal dementia with GRN mutation ( 29724592) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Triglyceride levels ( 34074324)	Biochemical measures ( 19260141) Body mass index ( 29273807) Body mass index (change over time) in chronic obstructive pulmonary disease ( 28044437) Body size at age 10 ( 32376654) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725) Coronary artery disease ( 26343387) Daytime nap ( 33568662) Depression ( 27089181) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Endometriosis ( 23472165) Hip circumference adjusted for BMI ( 28552196) Late-onset Alzheimer's disease ( 27770636) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pursuit maintenance gain ( 29064472) Pursuit maintenance gain in psychotic disorders ( 29064472) Refractive error ( 32231278) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Type 2 diabetes ( 30718926 32499647 30297969) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		16 interacting genes: BBS2 KSR1 KSR2 MAGED1 MFHAS1 PRKAR1A PRKAR2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J1 UBE2L6 UBE2N UBE2W WEE2-AS1	7 interacting genes: CYSRT1 KRTAP10-8 MAP2K1 MAPK1 MAPK3 PJA2 RAF1
Entrez ID		9867	283455
HPRD ID		11436	13952
Ensembl ID		ENSG00000198961	ENSG00000171435
Uniprot IDs		O43164	Q6VAB6
PDB IDs			2Y4I 5KKR 7JUQ 7JUR 7JUS 7JUT 7JUU 7JUV 7UMB
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity ATP Binding Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein-containing Complex Proteolysis Protein K11-linked Ubiquitination CAMP-dependent Protein Kinase Regulator Activity Protein Monoubiquitination TORC1 Signaling Negative Regulation Of TORC1 Signaling CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Protein Modification Process Nucleotide-activated Protein Kinase Complex Proteasomal Protein Catabolic Process MAP-kinase Scaffold Activity TOR Signaling Protein Kinase A Catalytic Subunit Binding Negative Regulation Of TOR Signaling Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Catabolic Process Negative Regulation Of Signal Transduction CAMP Binding Regulation Of Intracellular Signal Transduction Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of CAMP/PKA Signal Transduction Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Plasma Membrane Raft	ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Schwann Cell Development Face Development ERBB2 Signaling Pathway Regulation Of Golgi Inheritance Thyroid Gland Development Insulin-like Growth Factor Receptor Signaling Pathway Trachea Formation Thymus Development Bergmann Glial Cell Differentiation Glial Cell Development ERBB Signaling Pathway Regulation Of Golgi Organization Myelination Axon Ensheathment Regulation Of Early Endosome To Late Endosome Transport Hematopoietic Or Lymphoid Organ Development Pseudopodium Animal Organ Formation Lung Morphogenesis Astrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Interleukin-34-mediated Signaling Pathway MAPK Cascade ERK1 And ERK2 Cascade Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of MAPK Cascade Gland Development Cardiac Neural Crest Cell Development Involved In Heart Development Insulin Receptor Signaling Pathway Ciliary Basal Body Outer Ear Morphogenesis Protein Serine Kinase Activity Glial Cell Differentiation Protein Serine/threonine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade MAP Kinase Activity Type B Pancreatic Cell Proliferation Protein Kinase Activity Late Endosome Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuroinflammatory Response Stress-activated MAPK Cascade Epithelial Cell Proliferation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macrophage Migration
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