MTSS1 and RBCK1

Number of citations of the paper that reports this interaction (PubMedID 35122005)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		MTSS1	RBCK1
Description		MTSS I-BAR domain containing 1	RANBP2-type and C3HC4-type zinc finger containing 1
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytoskeleton Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Endocytic Vesicle	Cytosol LUBAC Complex
	Molecular Function	Actin Binding Actin Monomer Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Identical Protein Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Protein Sequestering Activity Ubiquitin Ligase Activator Activity
	Biological Process	Plasma Membrane Organization Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Microspike Assembly Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Adherens Junction Maintenance Negative Regulation Of Epithelial Cell Proliferation Renal Tubule Morphogenesis Cellular Response To Fluid Shear Stress Glomerulus Morphogenesis Nephron Tubule Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis	Protein Polyubiquitination Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Regulation Of Primary Metabolic Process Protein Linear Polyubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Cognitive performance in schizophrenia or bipolar disorder ( 31872970) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Irritable bowel syndrome ( 29626450) Left ventricle diastolic internal dimension ( 28394258) Left ventricular ejection fraction ( 31554410 32382064 33495596) Left ventricular end-systolic volume ( 32382064 33495596) Left ventricular global circumferential strain ( 33495596)	Femur bone mineral density x serum urate levels interaction ( 34046847) Night sleep phenotypes ( 27126917)
Interacting Genes		5 interacting genes: HTT MZF1 PTPRD RBCK1 RECQL5	71 interacting genes: ANKRD35 ANTXR1 APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MAP3K1 MAPKBP1 MKRN2 MTSS1 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RELA RIPPLY3 RNF181 RNF26 RNF31 SHARPIN SMURF1 SOCS6 SYCE1 TNF TNFAIP3 TP53 TRAF1 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414
Entrez ID		9788	10616
HPRD ID		12243	16643
Ensembl ID		ENSG00000170873	ENSG00000125826
Uniprot IDs		A5YM41 O43312	A0A8V8TMZ2 A6PVJ6 Q9BYM8
PDB IDs		2D1K	2CRC 2LGY 4DBG 7V8E 7YUI 7YUJ 8BVL 8EAZ 8K6Q 9EGV 9EGW
Enriched GO Terms of Interacting Partners?		Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Aggrephagy Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Lipophagy Positive Regulation Of CAMKK-AMPK Signaling Cascade Phosphoprotein Phosphatase Activity Identical Protein Binding Trans-synaptic Signaling By Trans-synaptic Complex Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Mitotic DNA Replication Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Nuclear DNA Replication Catalytic Activity, Acting On DNA Four-way Junction Helicase Activity Cellular Response To Camptothecin Mitotic DNA-templated DNA Replication LUBAC Complex Protein Linear Polyubiquitination Vocal Learning Regulation Of Organelle Assembly Observational Learning Presynaptic Membrane Assembly Profilin Binding Presynaptic Membrane Organization Chromosome Separation Presynapse Assembly 3'-5' DNA Helicase Activity Transcription Preinitiation Complex Ubiquitin Ligase Activator Activity Auditory Behavior Positive Regulation Of Cell Projection Organization Dynactin Binding Mechanosensory Behavior Regulation Of Postsynaptic Density Assembly Regulation Of Apoptotic Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Activity	Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Transferase Activity Catabolic Process Ubiquitin Protein Ligase Activity Protein K48-linked Ubiquitination Cysteine-type Peptidase Activity Ubiquitin Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Defense Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of DNA-templated Transcription Free Ubiquitin Chain Polymerization Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Catabolic Process
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