RBCK1 and IREB2

Number of citations of the paper that reports this interaction (PubMedID 17822790)
30

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		RBCK1	IREB2
Description		RANBP2-type and C3HC4-type zinc finger containing 1	iron responsive element binding protein 2
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GO Annotations	Cellular Component	Cytosol LUBAC Complex	Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Protein Sequestering Activity Ubiquitin Ligase Activator Activity	MRNA Regulatory Element Binding Translation Repressor Activity RNA Binding Aconitate Hydratase Activity Protein Binding Iron-responsive Element Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Regulation Of Primary Metabolic Process Protein Linear Polyubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Translation Protoporphyrinogen IX Biosynthetic Process Intracellular Iron Ion Homeostasis Post-embryonic Development Regulation Of Gene Expression Negative Regulation Of Translation Osteoclast Differentiation Erythrocyte Homeostasis MRNA Stabilization Intestinal Absorption Multicellular Organismal-level Iron Ion Homeostasis
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Antigen processing: Ubiquitination & Proteasome degradation	Iron uptake and transport
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Night sleep phenotypes ( 27126917)	Autism spectrum disorder or schizophrenia ( 28540026) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic obstructive pulmonary disease ( 22080838 20173748 25241909) Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774) Diffusing capacity of carbon monoxide ( 30694715) Emotional recognition ( 31596458) Emphysema distribution in smoking ( 27669027) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary artery enlargement in chronic obstructive pulmonary disease ( 25101718) Schizophrenia ( 29483656 25056061)
Interacting Genes		71 interacting genes: ANKRD35 ANTXR1 APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MAP3K1 MAPKBP1 MKRN2 MTSS1 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RELA RIPPLY3 RNF181 RNF26 RNF31 SHARPIN SMURF1 SOCS6 SYCE1 TNF TNFAIP3 TP53 TRAF1 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414	6 interacting genes: APP OTUD3 RBCK1 TERT USP53 YBX1
Entrez ID		10616	3658
HPRD ID		16643	08858
Ensembl ID		ENSG00000125826	ENSG00000136381
Uniprot IDs		A0A8V8TMZ2 A6PVJ6 Q9BYM8	P48200
PDB IDs		2CRC 2LGY 4DBG 7V8E 7YUI 7YUJ 8BVL 8EAZ 8K6Q 9EGV 9EGW	6VCD
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Transferase Activity Catabolic Process Ubiquitin Protein Ligase Activity Protein K48-linked Ubiquitination Cysteine-type Peptidase Activity Ubiquitin Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Defense Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of DNA-templated Transcription Free Ubiquitin Chain Polymerization Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Catabolic Process	Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Auditory Stimulus Negative Regulation Of Cellular Senescence Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Senescence TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Biological Quality Cysteine-type Deubiquitinase Activity Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Macromolecule Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization MiRNA Transport RNA-directed RNA Polymerase Activity RNA-templated Transcription Positive Regulation Of Hair Cycle RNA-directed DNA Polymerase Activity Telomerase Catalytic Core Complex Protein K6-linked Deubiquitination Protein Deubiquitination Protein Modification By Small Protein Removal Outer Hair Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway
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