FRMPD4 and STK36

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FRMPD4	STK36
Description		FERM and PDZ domain containing 4	serine/threonine kinase 36
Image			No pdb structure
GO Annotations	Cellular Component	Protein-containing Complex Cell Projection Dendritic Spine Synapse Postsynapse	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Cell Projection
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding	Nucleotide Binding Transcription Corepressor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Synapse Structural Plasticity	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Protein Phosphorylation Microtubule-based Process Smoothened Signaling Pathway Brain Development Post-embryonic Development Cell Projection Organization Axoneme Assembly Positive Regulation Of Smoothened Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Cilium Assembly
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Shoulder impingement or rotator cuff tear ( 33482370)	Amyotrophic lateral sclerosis ( 22959728) Body mass index and triglycerides (pairwise) ( 33619380) Hematocrit ( 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Male-pattern baldness ( 28196072) Red blood cell count ( 32888494) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: PPP1CA STK36	12 interacting genes: CDK5RAP2 CDK9 CLNK FRMPD4 GLI1 GLI2 GLI3 MAP1LC3B MAST2 MID1 NEIL3 SUFU
Entrez ID		9758	27148
HPRD ID		10011	09631
Ensembl ID		ENSG00000169933	ENSG00000163482
Uniprot IDs		A0A087WYX8 A0A5F9ZH12 A0A6Q8PH73 B7ZLE1 Q14CM0	A0A140VJW1 Q9NRP7
PDB IDs		4WND 4WNE 4WNF 4WNG 7BYJ
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex Double-strand Break Repair Via Alternative Nonhomologous End Joining RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Telomere Maintenance In Response To DNA Damage Protein Phosphatase Type 1 Complex Transition Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion Positive Regulation Of Glycogen Biosynthetic Process Response To Lead Ion Entrainment Of Circadian Clock By Photoperiod Regulation Of Translation In Response To Stress Negative Regulation Of Transcription Elongation By RNA Polymerase II Protein Phosphatase 1 Binding Negative Regulation Of DNA-templated Transcription, Elongation Photoperiodism Entrainment Of Circadian Clock Regulation Of Glycogen Biosynthetic Process Ribonucleoprotein Complex Binding Positive Regulation Of Protein-containing Complex Disassembly Regulation Of Glycogen Metabolic Process Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Glucose Metabolic Process Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Transcription Corepressor Binding Phosphate-containing Compound Metabolic Process DNA-templated Transcription Elongation Axoneme Assembly Glycogen Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Double-strand Break Repair Via Nonhomologous End Joining Animal Organ Development Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Carbohydrate Catabolic Process Circadian Regulation Of Gene Expression Protein Modification Process Positive Regulation Of Signal Transduction Energy Reserve Metabolic Process Phosphatase Activity	GLI-SUFU Complex Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Ciliary Base Spinal Cord Dorsal/ventral Patterning Ciliary Tip Dorsal/ventral Pattern Formation Smoothened Signaling Pathway Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Microtubule Binding Proximal/distal Pattern Formation Ventral Midline Development Double-stranded DNA Binding Hindgut Morphogenesis Pattern Specification Process Cerebellar Cortex Morphogenesis Regulation Of Smoothened Signaling Pathway Regionalization Tube Morphogenesis Lung Development Embryonic Digestive Tract Development Axoneme Osteoblast Differentiation Regulation Of Osteoblast Differentiation Pituitary Gland Development Negative Regulation Of Smoothened Signaling Pathway Mammary Gland Development Regulation Of Cell Differentiation Positive Regulation Of DNA Replication Artery Development Cilium Transcription Cis-regulatory Region Binding Notochord Regression Digestive Tract Development Lateral Semicircular Canal Development Sagittal Suture Morphogenesis Lambdoid Suture Morphogenesis Lateral Ganglionic Eminence Cell Proliferation Anterior Semicircular Canal Development Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug MCM Complex Binding Gland Development Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Ciliary Basal Body Negative Regulation Of Neuron Differentiation P-TEFb Complex Morphogenesis Of An Epithelium Semicircular Canal Development Mammary Gland Specification
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