CD58 and CD2

Number of citations of the paper that reports this interaction (PubMedID 11575926)
0

Data Source:
BioGRID (x-ray crystallography, pull down)
HPRD (in vitro)

		CD58	CD2
Description		CD58 molecule	CD2 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane	Extracellular Region Nucleoplasm Golgi Apparatus Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Protein-containing Complex
	Molecular Function	Signaling Receptor Binding Protein Binding	Signaling Receptor Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Immune Response Positive Regulation Of Interleukin-8 Production Heterotypic Cell-cell Adhesion Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion	Membrane Raft Polarization Apoptotic Process Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Natural Killer Cell Mediated Cytotoxicity Regulation Of T Cell Differentiation Cell-cell Adhesion
Pathways		Cell surface interactions at the vascular wall Neutrophil degranulation	Cell surface interactions at the vascular wall
Drugs			Alefacept Siplizumab
Diseases
GWAS		Multiple sclerosis ( 19525953 19525955 21244703 21833088 22190364 24076602 27386562 31604244) Primary biliary cholangitis ( 28425483) Systemic lupus erythematosus ( 33272962 33536424)	Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		4 interacting genes: APP CD2 DNAJA1 HERPUD1	23 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC RBM15 RHOC SH3KBP1 SP1 UBC
Entrez ID		965	914
HPRD ID		01081	01750
Ensembl ID		ENSG00000116815	ENSG00000116824
Uniprot IDs		P19256	P06729 Q53F96
PDB IDs		1CCZ 1CI5 1QA9	1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?		Regulation Of Intrinsic Apoptotic Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Protein-folding Chaperone Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Binding Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Type II Interferon Production Regulation Of Cellular Response To Stress Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Unfolded Protein Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Type II Interferon Production Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Membrane Raft Polarization Positive Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Lewy Body Core Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Response To Stress Positive Regulation Of Amyloid Fibril Formation	T Cell Receptor Signaling Pathway Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation T Cell Costimulation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Activation Gamma-delta T Cell Activation Plasma Membrane Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Immune Response-activating Signaling Pathway Leukocyte Activation Membrane Raft Negative Regulation Of Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation CD8 Receptor Binding Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Cell Activation Positive Regulation Of Cell Adhesion T Cell Activation Regulation Of Cell-cell Adhesion Natural Killer Cell Activation Fc Receptor Signaling Pathway CD4 Receptor Binding Positive Regulation Of Gamma-delta T Cell Differentiation Phospholipase Activator Activity Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Immune Response T Cell Receptor Binding Positive Regulation Of Leukocyte Differentiation Cell-cell Junction Extracellular Exosome Signaling Receptor Binding Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Multicellular Organismal Process
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