CD2 and CD2BP2

Number of citations of the paper that reports this interaction (PubMedID 9843987)
38

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CD2	CD2BP2
Description		CD2 molecule	CD2 cytoplasmic tail binding protein 2
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GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Golgi Apparatus Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Protein-containing Complex	Fibrillar Center Nucleus Nucleoplasm U5 SnRNP Cytoplasm Cytosol Nuclear Speck U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Membrane Raft Polarization Apoptotic Process Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Natural Killer Cell Mediated Cytotoxicity Regulation Of T Cell Differentiation Cell-cell Adhesion	Spliceosomal Tri-snRNP Complex Assembly MRNA Processing RNA Splicing
Pathways		Cell surface interactions at the vascular wall
Drugs		Alefacept Siplizumab
Diseases
GWAS		Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		23 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC RBM15 RHOC SH3KBP1 SP1 UBC	22 interacting genes: ACAD11 AKNA AP2M1 CD2 CHRM3 CPSF7 CSNK2A1 LRRK1 NAT10 OGT PRPF6 PSMF1 PTBP3 SF3B4 SFPQ SMU1 SNRPB SNRPN TRAPPC6A TXNL4A WBP11 ZNHIT2
Entrez ID		914	10421
HPRD ID		01750	05127
Ensembl ID		ENSG00000116824	ENSG00000169217
Uniprot IDs		P06729 Q53F96	A0A024QZC1 O95400
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I	1GYF 1L2Z 1SYX 4BWS 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8RC0
Enriched GO Terms of Interacting Partners?		T Cell Receptor Signaling Pathway Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation T Cell Costimulation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Activation Gamma-delta T Cell Activation Plasma Membrane Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Immune Response-activating Signaling Pathway Leukocyte Activation Membrane Raft Negative Regulation Of Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation CD8 Receptor Binding Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Cell Activation Positive Regulation Of Cell Adhesion T Cell Activation Regulation Of Cell-cell Adhesion Natural Killer Cell Activation Fc Receptor Signaling Pathway CD4 Receptor Binding Positive Regulation Of Gamma-delta T Cell Differentiation Phospholipase Activator Activity Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Immune Response T Cell Receptor Binding Positive Regulation Of Leukocyte Differentiation Cell-cell Junction Extracellular Exosome Signaling Receptor Binding Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Multicellular Organismal Process	MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions U5 SnRNP RNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process Spliceosomal Complex SnRNP Binding U2 SnRNP Nucleobase-containing Compound Metabolic Process Nucleoplasm RNA Binding Negative Regulation Of Proteasomal Protein Catabolic Process U4 SnRNP Protein-containing Complex Assembly Macromolecule Metabolic Process Protein-RNA Complex Assembly Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Small Nuclear Ribonucleoprotein Complex Catalytic Step 2 Spliceosome U2-type Prespliceosome Protein-containing Complex Organization U1 SnRNP Precatalytic Spliceosome Sin3-type Complex Telomerase Holoenzyme Complex U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Negative Regulation Of Protein Catabolic Process U2-type Spliceosomal Complex Negative Regulation Of Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly TRNA Acetylation MRNA N-acetyltransferase Activity TRNA Cytidine N4-acetyltransferase Activity TRNA Wobble Cytosine Modification RRNA Acetylation Involved In Maturation Of SSU-rRNA 18S RRNA Cytidine N-acetyltransferase Activity Neuroblast Delamination Spliceosomal SnRNP Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Cellular Component Assembly
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