TRAF4 and SIGLEC7

Number of citations of the paper that reports this interaction (PubMedID 10514511)
0

Data Source:
HPRD (in vivo, in vitro)

		TRAF4	SIGLEC7
Description		TNF receptor associated factor 4	sialic acid binding Ig like lectin 7
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Membrane Perinuclear Region Of Cytoplasm Anchoring Junction	Plasma Membrane Membrane
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding Metal Ion Binding WW Domain Binding	Protein Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity
	Biological Process	Immune System Process Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Respiratory Gaseous Exchange By Respiratory System Respiratory Tube Development Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade	Cell Adhesion
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			N-acetyl-alpha-D-glucosamine
Diseases
GWAS			High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		137 interacting genes: ABI3 ACTMAP ALKBH4 ANXA1 AR ATOSB ATOX1 BACH2 BAHD1 BANP BCKDK BCL6B BEGAIN BEX3 BYSL CALCOCO2 CAV1 CBL CBLC CCHCR1 CENPE CEP85 CHEK1 CHUK DISC1 DNM2 DPEP2NB DTX3 EXOC7 EYA2 EZHIP FAM90A1 FAT1 FBXL18 FRS3 FTH1 GOLGA2 GOLGA6A GOLGA6L9 GORASP1 GORASP2 GPRASP1 HEY2 HGS HMG20A HOMEZ HOXA1 HOXB5 IRAK1 IRS1 ISYNA1 KANK2 KANSL1 KDM1A KRT31 KRT36 LENG8 LNX1 LTBR MAGEC2 MAGED1 MAP3K4 MRPL28 NCF1 NGFR NHERF2 NOS1AP NPAS2 NTRK1 NUDT16L1 OGT PCSK5 PDE4DIP PHLDA1 PICK1 PKD1P1 PLAGL2 PLEKHA7 PLSCR1 POLR2J POLR2J3 PSMC3 QARS1 RAD54L2 RBPMS REXO1L6P RNF114 RNF144B RNF4 RPS6KB1 SF3B4 SIGLEC7 SMURF1 SMURF2 SNRPB SORBS2 SPDL1 SUMO1 TARBP2 TAX1BP1 TBC1D7 TBC1D8 TFAP4 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM27 TRIM37 TSGA10IP TYK2 UBC UBE2D1 UBE2I UBL4A UBL4B USP7 VPS52 WBP11 WWP1 WWP2 ZBTB16 ZBTB26 ZC3H12C ZMYM5 ZNF177 ZNF275 ZNF3 ZNF512B ZNF559-ZNF177 ZNF581 ZNF620 ZNF688 ZNF784 ZNF835 ZRANB1	5 interacting genes: GRB2 LGALS3BP PTPN11 SMIM1 TRAF4
Entrez ID		9618	27036
HPRD ID		03915	05102
Ensembl ID		ENSG00000076604	ENSG00000168995
Uniprot IDs		Q9BUZ4	Q9Y286
PDB IDs		2EOD 2YUC 3ZJB 4K8U 4M4E 5YC1	1NKO 1O7S 1O7V 2DF3 2G5R 2HRL
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Cytosol Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Regulation Of Transcription By RNA Polymerase II Ubiquitin-protein Transferase Activity Regulation Of Gene Expression Ubiquitin Protein Ligase Activity Post-translational Protein Modification Negative Regulation Of RNA Metabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Toll-like Receptor Signaling Pathway Identical Protein Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Cytoplasm Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination PML Body Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Biosynthetic Process Signaling Adaptor Activity Zinc Ion Binding Proteolysis Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process	Phosphotyrosine Residue Binding T Cell Costimulation Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Binding ERBB Signaling Pathway Guanyl-nucleotide Exchange Factor Adaptor Activity Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of MAPK Cascade Grb2-EGFR Complex Intestinal Epithelial Cell Migration Signal Transduction In Response To DNA Damage Cerebellar Cortex Formation Negative Regulation Of Glucocorticoid Secretion Neurotrophin TRKA Receptor Binding Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Branching Involved In Labyrinthine Layer Morphogenesis Insulin Receptor Substrate Binding Platelet Dense Granule Lumen Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Neutrophil Activation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Atrioventricular Canal Development Microvillus Organization Regulation Of Neutrophil Activation Regulation Of Growth Hormone Secretion Peptide Hormone Receptor Binding Negative Regulation Of Cell Adhesion Mediated By Integrin Bergmann Glial Cell Differentiation Neutrophil Activation Involved In Immune Response Thioesterase Binding Respiratory Tube Development
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