MTRF1 and NUDT15

		MTRF1	NUDT15
Description		mitochondrial translation release factor 1	nudix hydrolase 15
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion	Cytosol
	Molecular Function	Translation Release Factor Activity Translation Release Factor Activity, Codon Specific	Protein Binding 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Hydrolase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity 8-oxo-dGDP Phosphatase Activity Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity
	Biological Process	Translation Translational Termination Mitochondrial Translational Termination	Mitotic Cell Cycle Response To Reactive Oxygen Species Purine Nucleotide Catabolic Process DGTP Catabolic Process Response To Stress Purine Deoxyribonucleoside Triphosphate Catabolic Process Xenobiotic Catabolic Process DNA Protection Nucleobase-containing Small Molecule Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Nucleoside Phosphate Catabolic Process
Pathways		Mitochondrial translation termination	Phosphate bond hydrolysis by NUDT proteins Azathioprine ADME
Drugs
Diseases
GWAS		Keratoconus ( 33649486) Proportion of activated microglia (inferior temporal cortex) ( 30679421)	Estimated glomerular filtration rate ( 31015462) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		2 interacting genes: NUDT15 RB1	6 interacting genes: CDADC1 FNDC3A GABARAPL2 MTRF1 SRD5A3 UTP14C
Entrez ID		9617	55270
HPRD ID		06855	14848
Ensembl ID		ENSG00000120662	ENSG00000136159
Uniprot IDs		O75570	Q9NV35
PDB IDs		8OIN 8OIP 8OIQ 8OIR 8OIS 8OIT	5BON 5LPG 6T5J 7AOM 7AOP 7B63 7B64 7B65 7B66 7B67 7B7V 7NR6 7R0D
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Myofibroblast Differentiation Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process Enucleate Erythrocyte Differentiation Glial Cell Apoptotic Process Rb-E2F Complex Regulation Of Centromere Complex Assembly Chromatin Lock Complex Positive Regulation Of Collagen Fibril Organization 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity Purine Deoxyribonucleoside Triphosphate Catabolic Process 8-oxo-dGDP Phosphatase Activity DGTP Metabolic Process DGTP Catabolic Process Nucleoside Triphosphate Diphosphatase Activity 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity DNA Protection Deoxyribonucleoside Triphosphate Catabolic Process Regulation Of Myofibroblast Differentiation Regulation Of Collagen Fibril Organization Cyclin/CDK Positive Transcription Elongation Factor Complex Importin-alpha Family Protein Binding Deoxyribonucleoside Triphosphate Metabolic Process Positive Regulation Of Transcription Regulatory Region DNA Binding Nucleoside Triphosphate Catabolic Process Positive Regulation Of Macrophage Differentiation Hepatocyte Apoptotic Process Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of DNA Binding Cell Morphogenesis Involved In Neuron Differentiation Disordered Domain Specific Binding Positive Regulation Of Extracellular Matrix Organization Glial Cell Proliferation Negative Regulation Of Epithelial Cell Apoptotic Process Regulation Of Macrophage Differentiation Deoxyribose Phosphate Catabolic Process Deoxyribonucleotide Catabolic Process Xenobiotic Catabolic Process Neuron Maturation SWI/SNF Complex Myoblast Differentiation Positive Regulation Of Chromosome Separation Aortic Valve Morphogenesis Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Smoothened Signaling Pathway	Protein-containing Complex Disassembly Translation Release Factor Activity, Codon Specific Mitochondrial Translational Termination Polyprenol Reductase Activity 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity 3-oxo-5-alpha-steroid 4-dehydrogenase Activity Polyprenol Catabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Polyprenal Reductase Activity DCMP Deaminase Activity Translation Release Factor Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Androgen Biosynthetic Process DNA Cytosine Deamination Translational Termination Cellular Response To Nitrogen Starvation Importin-alpha Family Protein Binding Cytidine Deaminase Activity DNA Deamination Phosphatidylethanolamine Binding Protein Localization To Endoplasmic Reticulum GABA Receptor Binding Sertoli Cell Development Dolichol-linked Oligosaccharide Biosynthetic Process Positive Regulation Of ATP-dependent Activity
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