BAG2 and DNAJC6

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		BAG2	DNAJC6
Description		BAG cochaperone 2	DnaJ heat shock protein family (Hsp40) member C6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Microtubule Axon Dendrite Protein Folding Chaperone Complex Dendritic Microtubule	Cytoplasm Cytosol Postsynaptic Density Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Intracellular Membrane-bounded Organelle Synapse Extrinsic Component Of Presynaptic Endocytic Zone Membrane
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Transmembrane Transporter Binding Tau Protein Binding Protein-folding Chaperone Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity SH3 Domain Binding Clathrin Binding Heat Shock Protein Binding Clathrin Heavy Chain Binding
	Biological Process	Protein Folding Positive Regulation Of Protein Processing Protein Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Protein Stabilization Positive Regulation Of Proteasomal Protein Catabolic Process	Synaptic Vesicle Uncoating Synaptic Vesicle Recycling Intracellular Transport Clathrin Coat Disassembly Clathrin-dependent Endocytosis Regulation Of Clathrin Coat Assembly Regulation Of Clathrin-dependent Endocytosis
Pathways		Regulation of HSF1-mediated heat shock response	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Anticoagulant levels ( 22216198) Idiopathic osteonecrosis of the femoral head ( 28000841)
Interacting Genes		17 interacting genes: CCAR2 DAPK1 DISC1 DNAJC6 HSPA1A HSPA4 HSPA8 LRRK1 LRRK2 MAPKAPK2 MFHAS1 NOTCH3 PINK1 PPIH SLU7 WDR77 WDR83	3 interacting genes: AP2A2 BAG2 CLTC
Entrez ID		9532	9829
HPRD ID		04859	16326
Ensembl ID		ENSG00000112208	ENSG00000116675
Uniprot IDs		O95816	O75061
PDB IDs
Enriched GO Terms of Interacting Partners?		C3HC4-type RING Finger Domain Binding Cytoplasm Negative Regulation Of Intrinsic Apoptotic Signaling Pathway ATP-dependent Protein Folding Chaperone Nucleotide Binding ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Clathrin Coat Disassembly Positive Regulation Of Wnt Signaling Pathway Regulation Of Synaptic Vesicle Transport ATP Binding Protein Serine Kinase Activity Regulation Of Signal Transduction Regulation Of Protein Stability Protein-containing Complex Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis MRNA Metabolic Process Spliceosomal Complex RNA Splicing Response To Stress Protein Serine/threonine Kinase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Heat Shock Protein Binding MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Oxidative Stress Protein Folding Regulation Of Protein-containing Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Processing Cellular Response To Stress Negative Regulation Of Autophagosome Assembly Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Response To Unfolded Protein Protein Kinase Activity Adenyl-nucleotide Exchange Factor Activity Mitochondrion Organization Cellular Response To Chemical Stress Regulation Of Cellular Response To Stress Intracellular Signal Transduction Syntaxin-1 Binding Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Cytosol Calcium/calmodulin-dependent Protein Kinase Activity Ubiquitin Protein Ligase Binding	Endolysosome Membrane Disordered Domain Specific Binding Clathrin-coated Endocytic Vesicle Clathrin-dependent Endocytosis Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Clathrin-coated Pit Receptor-mediated Endocytosis Dendritic Microtubule Postsynaptic Neurotransmitter Receptor Internalization Clathrin Coat Of Trans-Golgi Network Vesicle Vesicle Uncoating Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Hyaluronan Biosynthetic Process Clathrin Complex Clathrin Coat Clathrin Coat Of Coated Pit Clathrin Light Chain Binding Clathrin Coat Disassembly Amyloid-beta Clearance By Transcytosis Clathrin Adaptor Complex AP-2 Adaptor Complex Endocytosis Protein Kinase Binding Transferrin Transport Adenyl-nucleotide Exchange Factor Activity Intracellular Protein Transport Mitotic Spindle Microtubule Clathrin Adaptor Activity Transcytosis Ubiquitin-specific Protease Binding Clathrin Coat Assembly Import Into Cell Low-density Lipoprotein Particle Receptor Binding Amyloid-beta Clearance Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Membrane Coat Negative Regulation Of Protein Localization To Plasma Membrane Protein Folding Chaperone Complex Protein Depolymerization Synaptic Vesicle Endocytosis Cytoplasmic Vesicle Presynaptic Endocytosis Regulation Of Mitotic Spindle Organization Iron Ion Transport Tau Protein Binding Ficolin-1-rich Granule Membrane Regulation Of Protein Processing Regulation Of Protein Maturation
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