EEF1E1 and ATR

Number of citations of the paper that reports this interaction (PubMedID 15680327)
0

Data Source:
HPRD (in vitro, in vivo)

		EEF1E1	ATR
Description		eukaryotic translation elongation factor 1 epsilon 1	ATR checkpoint kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Aminoacyl-tRNA Synthetase Multienzyme Complex	Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Chromosome Golgi Apparatus PML Body ATR-ATRIP Complex Site Of DNA Damage
	Molecular Function	Protein Binding	Nucleotide Binding DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity MutLalpha Complex Binding MutSalpha Complex Binding Histone H2AXS139 Kinase Activity Protein Serine Kinase Activity
	Biological Process	Translation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Cellular Senescence Positive Regulation Of Apoptotic Signaling Pathway	DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Nucleobase-containing Compound Metabolic Process DNA Replication DNA Repair Double-strand Break Repair Chromatin Remodeling DNA Damage Response Nuclear Envelope Organization Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Response To Mechanical Stimulus Replication Fork Processing Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To UV Interstrand Cross-link Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G2/M Transition Checkpoint Response To Arsenic-containing Substance Nuclear Membrane Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Response To Gamma Radiation Regulation Of Cellular Response To Stress Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cellular Response To Heat Positive Regulation Of Telomerase Catalytic Core Complex Assembly Protein Localization To Site Of Double-strand Break Regulation Of Double-strand Break Repair
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity	Meiotic synapsis Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs			Ceralasertib
Diseases			Alveolar rhabdomyosarcoma Seckel syndrome
GWAS		Coronary artery calcification ( 23870195) Refractive error ( 32231278) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)	Eosinophil count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 29403010 32888494) Red cell distribution width ( 28957414 32888494) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		7 interacting genes: ATM ATR CALCOCO2 CDC42 CEBPA FNDC3B NAT9	58 interacting genes: AATF ABL1 AP1B1 AP3B1 APBB1 ARHGEF1 ATM BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CHUK CLSPN CREB1 DCAF1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 ETAA1 ETV1 FANCA FANCD2 FANCI FLT1 H2AX KDR LIG4 MCM2 MCPH1 MRE11 MSH2 NBN NFE2L2 PA2G4 PARP1 PIK3CA POLD1 POLN PPP2R3A RAD17 RASSF1 RHEB RPA1 TP53 TREX1 UHRF1 UHRF2 UPF1 USP2-AS1 XPA XRCC5
Entrez ID		9521	545
HPRD ID		10931	08369
Ensembl ID		ENSG00000124802	ENSG00000175054
Uniprot IDs		O43324	Q13535
PDB IDs		2UZ8 4BL7 4BVX 4BVY 5BMU 5Y6L	5YZ0
Enriched GO Terms of Interacting Partners?		Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Histone H2AXS139 Kinase Activity DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Regulation Of Cellular Response To Heat Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Organelle Organization Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Localization To Site Of Double-strand Break Cellular Response To Gamma Radiation Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Macrophage Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Mitotic G2/M Transition Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Positive Regulation Of Telomere Maintenance Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Tubulin N-terminal-methionine Acetyltransferase Activity Regulation Of Cell Cycle Regulation Of Protein-containing Complex Assembly Regulation Of DNA Biosynthetic Process Positive Regulation Of Cellular Component Organization Protein Localization To Chromosome Regulation Of G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Positive Regulation Of Macroautophagy DNA Damage Checkpoint Signaling ATR-ATRIP Complex PML Body Response To Type II Interferon GBD Domain Binding Storage Vacuole Response To Vitamin B2 C/EBP Complex Positive Regulation Of Cellular Component Biogenesis Regulation Of Mitotic Nuclear Division	DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Nucleic Acid Metabolic Process Double-strand Break Repair Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Chromosome, Telomeric Region Mitotic DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process Mitotic DNA Integrity Checkpoint Signaling DNA Recombination Negative Regulation Of Cell Cycle Phase Transition Response To Stress Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Recombinational Repair Response To Ionizing Radiation Regulation Of Cell Cycle Process Response To Radiation Damaged DNA Binding Double-strand Break Repair Via Homologous Recombination Mitotic G2/M Transition Checkpoint Cellular Response To Radiation Chromosome Organization Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Primary Metabolic Process Response To Gamma Radiation Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Telomere Maintenance Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition
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