EIF4E2 and EIF4EBP3

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		EIF4E2	EIF4EBP3
Description		eukaryotic translation initiation factor 4E family member 2	eukaryotic translation initiation factor 4E binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	P-body Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Nucleus Cytoplasm Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ubiquitin Protein Ligase Binding MRNA Cap Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity
	Biological Process	Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translational Initiation Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Rescue Of Stalled Ribosome	Regulation Of Translation Negative Regulation Of Translation Negative Regulation Of Translational Initiation
Pathways		ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Height ( 25282103) Non-small cell lung cancer (survival) ( 21079520) Refractive error ( 32231278)	Metabolite levels ( 23823483) Serum immune biomarker levels ( 32066700)
Interacting Genes		53 interacting genes: ADAMTSL4 AMOTL2 APP ARIH1 ARIH2 CAB39 CARD9 CBY2 CCL24 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MGAT5B MIPOL1 MVK MYOG NECAB2 NOTCH2NLA PDE4DIP PRDM14 REL SAG SP140 SPAG5 SPRY2 TADA2A TCF4 TGFBRAP1 TLE5 TMCC2 TRIM27 TRIM54 UBC UBXN11 USHBP1 USP54 ZBTB9	3 interacting genes: BBS5 EIF4E EIF4E2
Entrez ID		9470	8637
HPRD ID		05798	09149
Ensembl ID		ENSG00000135930	ENSG00000243056
Uniprot IDs		A0A8I5KSA5 B8ZZ50 B8ZZL3 B9A023 O60573 Q53RG0 Q59FE1	O60516
PDB IDs		2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Protein Binding Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Protein Serine/threonine Kinase Binding Identical Protein Binding Supramolecular Fiber Organization Microtubule End Structural Molecule Activity Eukaryotic Initiation Factor 4E Binding Negative Regulation Of Protein Localization To Nucleus Morphogenesis Of An Epithelium	MRNA Cap Binding RNA Cap Binding RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Translation Initiation Factor Activity Translational Initiation P-body Eukaryotic Initiation Factor 4G Binding Negative Regulation Of Translation Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse Translation BBSome Regulation Of Translation Chromatoid Body Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Translation Factor Activity, RNA Binding Negative Regulation Of Type I Interferon-mediated Signaling Pathway Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Melanosome Transport Pigment Granule Localization Cellular Response To Dexamethasone Stimulus Postsynaptic Modulation Of Chemical Synaptic Transmission Behavioral Fear Response Behavioral Defense Response Rescue Of Stalled Ribosome
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