EIF4E2 and ARIH1

Number of citations of the paper that reports this interaction (PubMedID 35716664)
74

Data Source:
BioGRID (pull down)
HPRD (in vivo, two hybrid, in vitro)

		EIF4E2	ARIH1
Description		eukaryotic translation initiation factor 4E family member 2	ariadne RBR E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	P-body Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body SCF Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Lewy Body
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ubiquitin Protein Ligase Binding MRNA Cap Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translational Initiation Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Rescue Of Stalled Ribosome	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination PKR/eIFalpha Signaling
Pathways		ISG15 antiviral mechanism	ISG15 antiviral mechanism RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS		Height ( 25282103) Non-small cell lung cancer (survival) ( 21079520) Refractive error ( 32231278)
Interacting Genes		53 interacting genes: ADAMTSL4 AMOTL2 APP ARIH1 ARIH2 CAB39 CARD9 CBY2 CCL24 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MGAT5B MIPOL1 MVK MYOG NECAB2 NOTCH2NLA PDE4DIP PRDM14 REL SAG SP140 SPAG5 SPRY2 TADA2A TCF4 TGFBRAP1 TLE5 TMCC2 TRIM27 TRIM54 UBC UBXN11 USHBP1 USP54 ZBTB9	20 interacting genes: BIRC6 CCNE1 CDKN1B CRY1 DCUN1D1 EIF4E2 HSPB1 PCBP1 PLD1 RBX1 SEC31A SLC25A21-AS1 UBC UBE2D1 UBE2D3 UBE2E2 UBE2L3 UBE2L6 UBE2N VAV2
Entrez ID		9470	25820
HPRD ID		05798	05730
Ensembl ID		ENSG00000135930	ENSG00000166233
Uniprot IDs		A0A8I5KSA5 B8ZZ50 B8ZZL3 B9A023 O60573 Q53RG0 Q59FE1	Q9Y4X5
PDB IDs		2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN	1WD2 2M9Y 4KBL 4KC9 5TTE 5UDH 7B5L 7B5M 7B5N 7B5S
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Protein Binding Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Protein Serine/threonine Kinase Binding Identical Protein Binding Supramolecular Fiber Organization Microtubule End Structural Molecule Activity Eukaryotic Initiation Factor 4E Binding Negative Regulation Of Protein Localization To Nucleus Morphogenesis Of An Epithelium	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Post-translational Protein Modification Post-translational Protein Modification Protein Ubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Protein Modification Process Protein Monoubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process ISG15 Transferase Activity Cytosol Protein K11-linked Ubiquitination Protein Metabolic Process ISG15-protein Conjugation Ubiquitin-dependent Protein Catabolic Process Cell Cycle Phase Transition Ubiquitin-protein Transferase Activator Activity TORC1 Signaling Negative Regulation Of TORC1 Signaling Cytoplasm Negative Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Cul4A-RING E3 Ubiquitin Ligase Complex Macromolecule Catabolic Process Cell Cycle G1/S Phase Transition TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Response To Nutrient Levels Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination DNA Damage Response Ubiquitin Binding Ubiquitin-like Protein Transferase Activity Proteolysis Ubiquitin Ligase Complex Protein Neddylation Cullin Family Protein Binding
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