PCYT1B and PCYT1A

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PCYT1B	PCYT1A
Description		phosphate cytidylyltransferase 1B, choline	phosphate cytidylyltransferase 1A, choline
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Glycogen Granule
	Molecular Function	Catalytic Activity Choline-phosphate Cytidylyltransferase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Phosphatidylcholine Binding Identical Protein Binding	Catalytic Activity Choline-phosphate Cytidylyltransferase Activity Protein Binding Calmodulin Binding Lipid Binding Transferase Activity Nucleotidyltransferase Activity Phosphatidylcholine Binding Identical Protein Binding Protein Homodimerization Activity Molecular Function Inhibitor Activity
	Biological Process	Ovarian Follicle Development Lipid Metabolic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Spermatogenesis Phospholipid Biosynthetic Process Phosphatidylcholine Metabolic Process Organophosphate Biosynthetic Process	Lipid Metabolic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Phospholipid Biosynthetic Process B Cell Proliferation Isotype Switching Phosphatidylcholine Metabolic Process Organophosphate Biosynthetic Process
Pathways		Synthesis of PC	Synthesis of PC
Drugs		Choline Choline salicylate	Choline Choline salicylate
Diseases
GWAS			Mean platelet volume ( 32888494)
Interacting Genes		7 interacting genes: ACTA1 ACTA2 APP ECPAS PAXIP1 PCYT1A TMEM43	16 interacting genes: ACTB AGTRAP CASP6 CASP8 FKBP7 GYS1 MAGEA3 MOB1A MOB3C PCYT1B RBM11 RNF8 SCAMP1 SDCBP SNAPIN TNFRSF10D
Entrez ID		9468	5130
HPRD ID		05376	00438
Ensembl ID		ENSG00000102230	ENSG00000161217
Uniprot IDs		Q9Y5K3	B4E322 P49585
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Body Mesenchyme Migration Positive Regulation Of Hepatic Stellate Cell Contraction Positive Regulation Of Cell Activation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Filopodium Positive Regulation Of Gene Expression Stress Fiber Juxtaglomerular Apparatus Development Positive Regulation Of Hepatic Stellate Cell Migration Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Choline-phosphate Cytidylyltransferase Activity Chorion Development Glomerular Mesangial Cell Development Mesangial Cell Development Positive Regulation Of Hepatic Stellate Cell Activation Smooth Muscle Contractile Fiber Regulation Of Cell Activation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Endoplasmic Reticulum Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Lamellipodium Skeletal Muscle Thin Filament Assembly Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway
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