PCYT1A and MOB3C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PCYT1A	MOB3C
Description		phosphate cytidylyltransferase 1A, choline	MOB kinase activator 3C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Glycogen Granule	Nucleus Cytoplasm
	Molecular Function	Catalytic Activity Choline-phosphate Cytidylyltransferase Activity Protein Binding Calmodulin Binding Lipid Binding Transferase Activity Nucleotidyltransferase Activity Phosphatidylcholine Binding Identical Protein Binding Protein Homodimerization Activity Molecular Function Inhibitor Activity	Protein Binding Protein Kinase Activator Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Phospholipid Biosynthetic Process B Cell Proliferation Isotype Switching Phosphatidylcholine Metabolic Process Organophosphate Biosynthetic Process	Signal Transduction
Pathways		Synthesis of PC
Drugs		Choline Choline salicylate
Diseases
GWAS		Mean platelet volume ( 32888494)	Chronic kidney disease ( 30226566) Hypertension ( 30226566)
Interacting Genes		16 interacting genes: ACTB AGTRAP CASP6 CASP8 FKBP7 GYS1 MAGEA3 MOB1A MOB3C PCYT1B RBM11 RNF8 SCAMP1 SDCBP SNAPIN TNFRSF10D	18 interacting genes: APP CMTM3 FAM118A FBXO7 IKZF4 KANK2 KRT40 LATS1 LATS2 NT5C2 PCYT1A PICK1 PTPN21 SIAH1 TDO2 TFCP2 TNIP1 ZBTB10
Entrez ID		5130	148932
HPRD ID		00438	17584
Ensembl ID		ENSG00000161217	ENSG00000142961
Uniprot IDs		B4E322 P49585	Q70IA8 X6R3L3
PDB IDs
Enriched GO Terms of Interacting Partners?			Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Amide Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signaling Amyloid Fibril Formation Regulation Of Protein Localization To Nucleus Cytosol Positive Regulation Of Receptor Internalization Negative Regulation Of Cell Communication Identical Protein Binding Phosphate-containing Compound Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Hippo Signaling Negative Regulation Of Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Hippo Signaling Amyloid-beta Complex Protein Homooligomerization Growth Cone Lamellipodium Neuron Projection Organization Negative Regulation Of Wnt Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Protein Modification Process L-tryptophan Catabolic Process To Acetyl-CoA Regulation Of Hippo Signaling Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nucleoside Phosphotransferase Activity GMP Catabolic Process To Guanine Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of NLRP3 Inflammasome Complex Assembly Protein Metabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Receptor-mediated Endocytosis Acetylcholine Receptor Activator Activity Positive Regulation Of Apoptotic Process Lipoprotein Particle Positive Regulation Of Protein Import Glial Cell Development
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