PIGS and SPP2

		PIGS	SPP2
Description		phosphatidylinositol glycan anchor biosynthesis class S	secreted phosphoprotein 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GPI-anchor Transamidase Complex	Extracellular Region Endoplasmic Reticulum Lumen Platelet Dense Granule Lumen Protein-containing Complex
	Molecular Function	Protein Binding	Endopeptidase Inhibitor Activity
	Biological Process	GPI Anchor Biosynthetic Process Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis	Skeletal System Development Bone Remodeling Protein-containing Complex Assembly
Pathways		Attachment of GPI anchor to uPAR	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS			Cognitive decline (age-related) ( 28078323) Hair greying ( 26926045) Osteoporosis-related phenotypes ( 20548944) Triglyceride levels ( 30108155)
Interacting Genes		22 interacting genes: COL6A1 CPEB2 CYB5D2 GGT6 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP19-2 KRTAP2-3 KRTAP2-4 KRTAP6-3 KRTAP9-2 NBPF19 NOTCH2NLA PDYN SPP2 TRIP6 TXNDC17 ZMYND15 ZNF701	1 interacting genes: PIGS
Entrez ID		94005	6694
HPRD ID		15135	04029
Ensembl ID		ENSG00000087111	ENSG00000072080
Uniprot IDs		Q8NBL9 Q96IR5 Q96S52	Q13103
PDB IDs		7W72 7WLD 8IMX 8IMY
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament	GPI-anchor Transamidase Complex Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Glycerophospholipid Biosynthetic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Phospholipid Metabolic Process Protein Maturation Glycerolipid Metabolic Process
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