SPP2 and PIGS

		SPP2	PIGS
Description		secreted phosphoprotein 2	phosphatidylinositol glycan anchor biosynthesis class S
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Platelet Dense Granule Lumen Protein-containing Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GPI-anchor Transamidase Complex
	Molecular Function	Endopeptidase Inhibitor Activity	Protein Binding
	Biological Process	Skeletal System Development Bone Remodeling Protein-containing Complex Assembly	GPI Anchor Biosynthetic Process Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Attachment of GPI anchor to uPAR
Drugs
Diseases
GWAS		Cognitive decline (age-related) ( 28078323) Hair greying ( 26926045) Osteoporosis-related phenotypes ( 20548944) Triglyceride levels ( 30108155)
Interacting Genes		1 interacting genes: PIGS	22 interacting genes: COL6A1 CPEB2 CYB5D2 GGT6 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP19-2 KRTAP2-3 KRTAP2-4 KRTAP6-3 KRTAP9-2 NBPF19 NOTCH2NLA PDYN SPP2 TRIP6 TXNDC17 ZMYND15 ZNF701
Entrez ID		6694	94005
HPRD ID		04029	15135
Ensembl ID		ENSG00000072080	ENSG00000087111
Uniprot IDs		Q13103	Q8NBL9 Q96IR5 Q96S52
PDB IDs			7W72 7WLD 8IMX 8IMY
Enriched GO Terms of Interacting Partners?		GPI-anchor Transamidase Complex Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Glycerophospholipid Biosynthetic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Phospholipid Metabolic Process Protein Maturation Glycerolipid Metabolic Process	Intermediate Filament Keratin Filament
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