ARHGAP18 and PALS2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		ARHGAP18	PALS2
Description		Rho GTPase activating protein 18	protein associated with LIN7 2, MAGUK p55 family member
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoplasmic Microtubule Plasma Membrane Nuclear Speck	Plasma Membrane Cell-cell Junction Membrane Organelle Extracellular Exosome
	Molecular Function	GTPase Activator Activity Cadherin Binding	Protein Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Motility	Protein-containing Complex Assembly
Pathways		RHOA GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Axial length ( 24144296) Cognitive function ( 24684796) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629)
Interacting Genes		3 interacting genes: BCS1L MPHOSPH6 PALS2	37 interacting genes: AATF ABCA1 ADGRA1 ARF5 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MKRN2 MT2P1 MTREX NDN NFKB1 OGT OSBPL3 PARN PTF1A RPS20 SMARCA4 SNX9 TACR3 THOP1 VPS26C WEE2-AS1
Entrez ID		93663	51678
HPRD ID		12474	09509
Ensembl ID		ENSG00000146376	ENSG00000105926
Uniprot IDs		Q8N392	B8ZZG1 Q9NZW5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Insertion Into Mitochondrial Inner Membrane Mitochondrial Cytochrome C Oxidase Assembly NADH Dehydrogenase Complex Assembly Respiratory Chain Complex IV Assembly Respiratory Chain Complex III Mitochondrial Respiratory Chain Complex III Assembly Inner Mitochondrial Membrane Organization Establishment Of Protein Localization To Mitochondrial Membrane Mitochondrial Respiratory Chain Complex I Assembly Cytochrome Complex Assembly Protein Insertion Into Mitochondrial Membrane Protein Insertion Into Mitochondrial Inner Membrane From Matrix Maturation Of 5.8S RRNA Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Organelle Protein Insertion Into Membrane Establishment Of Protein Localization To Mitochondrion Protein-containing Complex Assembly Mitochondrial Respiratory Chain Complex Assembly	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing MRNA Catabolic Process RNA Catabolic Process Exoribonuclease Complex SnRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process RRNA 3'-end Processing TRNA Decay RRNA Processing RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleolus RNA Metabolic Process CUT Catabolic Process RNA Processing Negative Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Macromolecule Catabolic Process DNA Deamination Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA Cytoplasm Catabolic Process DNA Modification Negative Regulation Of Macromolecule Metabolic Process
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