PALS2 and EIF3G

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		PALS2	EIF3G
Description		protein associated with LIN7 2, MAGUK p55 family member	eukaryotic translation initiation factor 3 subunit G
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Membrane Organelle Extracellular Exosome	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding
	Biological Process	Protein-containing Complex Assembly	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Viral Translational Termination-reinitiation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS
Interacting Genes		37 interacting genes: AATF ABCA1 ADGRA1 ARF5 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MKRN2 MT2P1 MTREX NDN NFKB1 OGT OSBPL3 PARN PTF1A RPS20 SMARCA4 SNX9 TACR3 THOP1 VPS26C WEE2-AS1	29 interacting genes: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 LMNA MEOX2 METTL3 MIF4GD MPHOSPH6 OGT PALS2 PIN1 PKN2 POT1 PRKAG1 SMN1 SNCA TK1 TRIM14
Entrez ID		51678	8666
HPRD ID		09509	04886
Ensembl ID		ENSG00000105926	ENSG00000130811
Uniprot IDs		B8ZZG1 Q9NZW5	O75821
PDB IDs			2CQ0 2MJC 5K0Y 6YBS 6ZMW 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8XXM 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing MRNA Catabolic Process RNA Catabolic Process Exoribonuclease Complex SnRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process RRNA 3'-end Processing TRNA Decay RRNA Processing RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleolus RNA Metabolic Process CUT Catabolic Process RNA Processing Negative Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Macromolecule Catabolic Process DNA Deamination Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA Cytoplasm Catabolic Process DNA Modification Negative Regulation Of Macromolecule Metabolic Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translational Initiation Translation Initiation Factor Activity Protein-containing Complex Assembly Protein-containing Complex Organization Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Cellular Component Assembly Regulation Of Translational Initiation Protein-RNA Complex Assembly Regulation Of Translation Viral Translational Termination-reinitiation Translation Post-transcriptional Regulation Of Gene Expression Cytoplasm IRES-dependent Viral Translational Initiation Macromolecule Metabolic Process Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process RNA Binding Cytosol Telomere Assembly Protein Tetramerization Protein Metabolic Process Nucleus Phosphoprotein Binding Cap-dependent Translational Initiation Shelterin Complex Negative Regulation Of Protein Catabolic Process Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process Nuclear Telomere Cap Complex Positive Regulation Of Translation Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Biosynthetic Process Telomere Capping Protein-containing Complex Establishment Of Protein Localization To Organelle Regulation Of ATP Metabolic Process Positive Regulation Of Protein Metabolic Process Nuclear Body Regulation Of Purine Nucleotide Metabolic Process Regulation Of Protein Catabolic Process
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